Yücesoy Sera Nur, Ak Tumay, Öner Sena, Serdaroğlu Server
Department of Dermatology, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Department of Internal Medicine, Cerrahpasa Medical Faculty, Istanbul University-Cerrahpasa, Istanbul, Turkey.
Skin Appendage Disord. 2024 Dec;10(6):490-496. doi: 10.1159/000539224. Epub 2024 Jun 11.
Recent studies showed that antimicrobial peptides have an essential role in the pathogenesis of acne vulgaris. This study aims to investigate serum catestatin levels in acne vulgaris patients and focuses on the change in serum levels after systemic isotretinoin therapy.
This prospective study includes 101 acne vulgaris patients and 28 healthy controls. Serum catestatin levels were measured and compared between acne vulgaris and control group patients. Also, serum catestatin levels were measured again at the 24th week of isotretinoin therapy.
The serum catestatin levels in patients with acne vulgaris were statistically higher than in the control group ( < 0.001). In addition, serum catestatin levels were associated with the severity of acne vulgaris. A significant decrease in serum catestatin levels was detected after 24 weeks of systemic isotretinoin treatment.
Catestatin was found to be significantly higher in the serum of patients with acne vulgaris compared to the control group. Although, the demonstration that catestatin levels decrease with isotretinoin treatment may indicate that it may have an important role in the pathogenesis of acne and could be used as a biomarker, future studies are needed to establish the role of catestatin in the pathogenesis of acne vulgaris.
近期研究表明，抗菌肽在寻常痤疮的发病机制中起重要作用。本研究旨在调查寻常痤疮患者的血清抑胃肽水平，并重点关注全身异维A酸治疗后血清水平的变化。
这项前瞻性研究纳入了101例寻常痤疮患者和28名健康对照者。测量并比较寻常痤疮患者与对照组患者的血清抑胃肽水平。此外，在异维A酸治疗的第24周再次测量血清抑胃肽水平。
寻常痤疮患者的血清抑胃肽水平在统计学上高于对照组（<0.001）。此外，血清抑胃肽水平与寻常痤疮的严重程度相关。全身异维A酸治疗24周后，血清抑胃肽水平显著下降。
发现寻常痤疮患者血清中的抑胃肽水平明显高于对照组。虽然，抑胃肽水平随异维A酸治疗而降低这一现象可能表明它在痤疮发病机制中可能起重要作用，并可作为一种生物标志物，但仍需要进一步研究来确定抑胃肽在寻常痤疮发病机制中的作用。
