Brzezińska Paulina, Mieszkowski Jan, Stankiewicz Błażej, Kowalik Tomasz, Reczkowicz Joanna, Niespodziński Bartłomiej, Durzyńska Aleksandra, Kowalski Konrad, Borkowska Andżelika, Antosiewicz Jędrzej, Kochanowicz Andrzej
Department of Gymnastics and Dance, Gdańsk University of Physical Education and Sport, Gdańsk, Poland.
Faculty of Physical Education and Sport, Charles University, Prague, Czechia.
Front Physiol. 2024 Nov 26;15:1462289. doi: 10.3389/fphys.2024.1462289. eCollection 2024.
Tryptophan (TRP) degradation through the kynurenine pathway is responsible for converting 95% of free TRP into kynurenines, which modulate skeletal muscle bioenergetics, immune and central nervous system activity. Therefore, changes in the kynurenines during exercise have been widely studied but not in the context of the effects of remote ischemic preconditioning (RIPC). In this study, we analyzed the effect of 14-day RIPC training on kynurenines and TRP in runners after running intervals of 20 × 400 m.
In this study, 27 semi-professional long-distance runners were assigned to two groups: a RIPC group performing 14 days of RIPC training (n = 12), and a placebo group, SHAM (n = 15). Blood was collected for analysis before, immediately after, and at 6 h and 24 h after the run.
After the 14-day RIPC/SHAM intervention, analysis showed a significantly lower concentration of XANA and kynurenic acid to kynurenine ratio (KYNA/KYN) in the RIPC group than in the SHAM group immediately after the running test. Conversely, the decrease in serum TRP levels was higher in the RIPC population.
RIPC modulates post-exercise changes in XANA and TRP levels, which can affect brain health, yet further research is needed.
通过犬尿氨酸途径进行的色氨酸（TRP）降解负责将95%的游离TRP转化为犬尿氨酸，后者可调节骨骼肌生物能量学、免疫和中枢神经系统活动。因此，运动过程中犬尿氨酸的变化已得到广泛研究，但尚未在远程缺血预处理（RIPC）的影响背景下进行研究。在本研究中，我们分析了14天RIPC训练对20×400米间歇跑后跑步者体内犬尿氨酸和TRP的影响。
在本研究中，27名半专业长跑运动员被分为两组：进行14天RIPC训练的RIPC组（n = 12）和假手术组（SHAM，n = 15）。在跑步前、跑步结束后立即以及跑步后6小时和24小时采集血液进行分析。
在14天的RIPC/SHAM干预后，分析显示跑步测试结束后，RIPC组的黄尿酸（XANA）浓度和犬尿喹啉酸与犬尿氨酸的比值（KYNA/KYN）显著低于SHAM组。相反，RIPC组血清TRP水平的下降幅度更大。
RIPC可调节运动后XANA和TRP水平的变化，这可能会影响大脑健康，但仍需进一步研究。
