Department of Gymnastics and Dance, Gdansk University of Physical Education and Sport, Kazimierza Gorskiego 1, 80-336 Gdansk, Poland.
Faculty of Physical Education and Sport, Charles University, 162 52 Prague, Czech Republic.
Nutrients. 2022 Oct 25;14(21):4485. doi: 10.3390/nu14214485.
In humans, most free tryptophan is degraded via kynurenine pathways into kynurenines. Kynurenines modulate the immune system, central nervous system, and skeletal muscle bioenergetics. Consequently, kynurenine pathway metabolites (KPMs) have been studied in the context of exercise. However, the effect of vitamin D supplementation on exercise-induced changes in KPMs has not been investigated. Here, we analyzed the effect of a single high-dose vitamin D supplementation on KPMs and tryptophan levels in runners after an ultramarathon. In the study, 35 amateur runners were assigned into two groups: vitamin D supplementation group, administered 150,000 IU vitamin D in vegetable oil 24 h before the run ( = 16); and control (placebo) group ( = 19). Blood was collected for analysis 24 h before, immediately after, and 24 h after the run. Kynurenic, xanthurenic, quinolinic, and picolinic acids levels were significantly increased after the run in the control group, but the effect was blunted by vitamin D supplementation. Conversely, the decrease in serum tryptophan, tyrosine, and phenylalanine levels immediately after the run was more pronounced in the supplemented group than in the control. The 3-hydroxy-l-kynurenine levels were significantly increased in both groups after the run. We conclude that vitamin D supplementation affects ultramarathon-induced changes in tryptophan metabolism.
在人类中，大多数游离色氨酸通过犬尿氨酸途径降解为犬尿氨酸。犬尿氨酸调节免疫系统、中枢神经系统和骨骼肌生物能量学。因此，在运动背景下研究了犬尿氨酸途径代谢物（KPM）。然而，维生素 D 补充对运动诱导的 KPM 变化的影响尚未得到研究。在这里，我们分析了单次大剂量维生素 D 补充对超马拉松赛后跑步者 KPM 和色氨酸水平的影响。在这项研究中，35 名业余跑步者被分为两组：维生素 D 补充组，在跑步前 24 小时给予 150,000IU 维生素 D 油（ = 16）；和对照组（安慰剂）（ = 19）。在跑步前 24 小时、跑步后立即和跑步后 24 小时采集血液进行分析。对照组在跑步后犬尿氨酸、黄尿酸、喹啉酸和烟酸水平显著升高，但维生素 D 补充可减轻这种作用。相反，补充组在跑步后立即血清色氨酸、酪氨酸和苯丙氨酸水平的下降比对照组更为明显。两组在跑步后 3-羟基-L-犬尿氨酸水平均显著升高。我们得出结论，维生素 D 补充会影响超马拉松引起的色氨酸代谢变化。
