Individuals with hematologic malignancy have increased risk of latent tuberculosis infection (LTBI) reactivation and (SS) dissemination. However, screening prior to chemotherapy or corticosteroids is not routine. We conducted a LTBI and SS screening intervention amongst patients with hematologic malignancies. Over one-third immigrated from countries with high TB incidence and SS prevalence, and some had additional risk factors (HIV, HTLV-1, eosinophilia). The intervention increased screening rates but universal screening was not achieved. Screening positivity was similar pre- and post-intervention. We demonstrate a population with increased indolent infection reactivation risk. Specific infectious screening guidelines are needed to prevent significant morbidity.