Karlin Hannah, Larson Martin, Rong Jian, Huan Tianxiao, Courchesne Paul, Freedman Jane E, Ho Jennifer E, Tanriverdi Kahraman, Mueller Gregory P, Levy Daniel
Framingham Heart Study Framingham, MA, USA.
Population Sciences Branch, National Heart, Lung, and Blood Institute, National Institutes of Health Bethesda, MD, USA.
Am J Cancer Res. 2024 Nov 25;14(11):5568-5572. doi: 10.62347/KMFI7371. eCollection 2024.
Breast cancer is the second leading cause of cancer deaths among women. Multiple microRNAs (miRNAs) have been reported to be associated with breast cancer progression or metastasis. The purpose of the current study was to identify plasma extracellular miRNAs associated with incident breast cancer. Levels of 166 plasma miRNA were measured using qRT-PCR in 2140 Framingham Heart Study female participants with a median follow up of 15.7 years. Prospective analyses of the associations of miRNAs with the occurrence of 56 new-onset breast cancer events were conducted using proportional hazards regression. The expression levels miR-134-5p (P=0.002) and miR-505-3p (P=0.005) were found to be positively associated with incident breast cancer after adjusting for age, body mass index, and cigarette smoking. These results highlight plasma miRNAs as potential biomarkers of breast cancer risk. Validation of these findings in larger and more diverse cohorts is warranted.
乳腺癌是女性癌症死亡的第二大主要原因。据报道，多种微小RNA（miRNA）与乳腺癌进展或转移有关。本研究的目的是确定与新发乳腺癌相关的血浆细胞外miRNA。在2140名弗雷明汉心脏研究女性参与者中，使用qRT-PCR测量了166种血浆miRNA的水平，中位随访时间为15.7年。使用比例风险回归对miRNA与56例新发乳腺癌事件发生之间的关联进行前瞻性分析。在调整年龄、体重指数和吸烟因素后，发现miR-134-5p（P=0.002）和miR-505-3p（P=0.005）的表达水平与新发乳腺癌呈正相关。这些结果突出了血浆miRNA作为乳腺癌风险潜在生物标志物的作用。有必要在更大、更多样化的队列中验证这些发现。
