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Reactive oxygen species mediate ovarian cancer development, platinum resistance, and angiogenesis via CXCL8 and GSK-3β/p70S6K1 axis.

作者信息

Qiu Jiange, Xu Qing, Panah Tahira, Morshed A K M Helal, Wang Xue, Zhou Fengmei, Liu Wenjing, Wang Jufeng, Zhang Ye, Liu Bingjie, Jiang Bing-Hua

机构信息

The First Affiliated Hospital of Zhengzhou University, The Academy of Medical Science, Zhengzhou University, Zhengzhou, Henan 450000, China.

Department of Pathology, Nanjing Medical University, Nanjing, Jiangsu 210029, China.

出版信息

Genes Dis. 2024 Jul 17;12(2):101378. doi: 10.1016/j.gendis.2024.101378. eCollection 2025 Mar.

DOI:10.1016/j.gendis.2024.101378
PMID:39660100
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11629555/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fd/11629555/c1709aa070ab/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fd/11629555/c1709aa070ab/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/84fd/11629555/c1709aa070ab/gr1.jpg

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本文引用的文献

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ROS are evolutionary conserved cell-to-cell stress signals.ROS 是进化上保守的细胞间应激信号。
Proc Natl Acad Sci U S A. 2023 Aug;120(31):e2305496120. doi: 10.1073/pnas.2305496120. Epub 2023 Jul 26.
2
Potential clinical utility of liquid biopsies in ovarian cancer.液体活检在卵巢癌中的潜在临床应用。
Mol Cancer. 2022 May 11;21(1):114. doi: 10.1186/s12943-022-01588-8.
3
The role of ROS in tumour development and progression.活性氧物质在肿瘤发生发展中的作用。
Nat Rev Cancer. 2022 May;22(5):280-297. doi: 10.1038/s41568-021-00435-0. Epub 2022 Jan 31.
4
ROS-induced ROS release orchestrated by Nox4, Nox2, and mitochondria in VEGF signaling and angiogenesis.在血管内皮生长因子信号传导和血管生成过程中，由Nox4、Nox2和线粒体精心编排的活性氧诱导的活性氧释放。
Am J Physiol Cell Physiol. 2017 Jun 1;312(6):C749-C764. doi: 10.1152/ajpcell.00346.2016. Epub 2017 Apr 19.