Yue Yang, Chen Chang, Liu Yunqi, Kong Derong, Wei Dacheng
State Key Laboratory of Molecular Engineering of Polymers, Fudan University, Shanghai 200433, China.
Department of Macromolecular Science, Fudan University, Shanghai 200433, China.
ACS Appl Mater Interfaces. 2024 Dec 25;16(51):70160-70173. doi: 10.1021/acsami.4c18412. Epub 2024 Dec 11.
In recent years, field-effect transistor (FET) sensing technology has attracted significant attention owing to its noninvasive, label-free, real-time, and user-friendly detection capabilities. Owing to the large specific surface area, high flexibility, and excellent conductivity of two-dimensional (2D) materials, FET biosensors based on 2D materials have demonstrated unique potential in biomarker analysis and healthcare applications, driving continuous innovation and transformation in the field. Here, we review recent trends in the development of 2D FET biosensors based on key performance metrics and main characteristics, and we also discuss structural designs and modification strategies for biosensing devices utilizing graphene, transition metal dichalcogenides, black phosphorus, and other 2D materials to enhance key performance metrics. Finally, we offer insights into future directions for biosensor advancements, discuss potential improvements, and present new recommendations for practical clinical applications.
近年来，场效应晶体管（FET）传感技术因其具有非侵入性、无标记、实时且用户友好的检测能力而备受关注。由于二维（2D）材料具有大的比表面积、高柔韧性和优异的导电性，基于2D材料的FET生物传感器在生物标志物分析和医疗保健应用中展现出独特的潜力，推动了该领域的持续创新与变革。在此，我们基于关键性能指标和主要特性综述了基于二维材料的场效应晶体管生物传感器的最新发展趋势，并且我们还讨论了利用石墨烯、过渡金属二硫属化物、黑磷和其他二维材料来提高关键性能指标的生物传感装置的结构设计和修饰策略。最后，我们深入探讨了生物传感器未来的发展方向，讨论了潜在的改进之处，并为实际临床应用提出了新的建议。
