Shu Chien-Gene Lay Department of Bioengineering, Jacobs School of Engineering, University of California, San Diego, La Jolla, CA, USA.
Division of Geriatrics, Gerontology and Palliative Care, Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA, USA.
Adv Biochem Eng Biotechnol. 2024;187:37-70. doi: 10.1007/10_2024_252.
This chapter provides a comprehensive overview of the principles, applications, and advancements in graphene field-effect transistor (gFET) biosensors for biological sensing. The unique properties of graphene that make it ideal for biosensing, including its high conductivity, chemical stability, and ability to facilitate label-free detection, will be discussed. The chapter also explores various applications of gFET biosensors, from detecting pH and salinity changes to complex protein-protein interactions and DNA/RNA sensing. It also addresses the challenges and future directions in gFET biosensor technology, emphasizing the need for scalable manufacturing, sophisticated surface chemistry, and the integration of multiomics approaches to enhance biosensing capabilities.
本章提供了一个关于石墨烯场效应晶体管（gFET）生物传感器在生物传感方面的原理、应用和进展的全面概述。我们将讨论石墨烯作为生物传感的理想材料的独特性质，包括其高导电性、化学稳定性和促进无标记检测的能力。本章还探讨了 gFET 生物传感器的各种应用，从检测 pH 值和盐度变化到复杂的蛋白质-蛋白质相互作用和 DNA/RNA 传感。它还解决了 gFET 生物传感器技术中的挑战和未来方向，强调需要可扩展的制造、复杂的表面化学和多组学方法的整合，以提高生物传感能力。
