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二维材料在即时检测设备中先进电子生物传感器中的应用。

2D Materials in Advanced Electronic Biosensors for Point-of-Care Devices.

机构信息

Department of Electrical Engineering, Sejong University, Seoul, 05006, Republic of Korea.

Department of Convergence Engineering for Intelligent Drone, Sejong University, Seoul, 05006, Republic of Korea.

出版信息

Adv Sci (Weinh). 2024 Aug;11(31):e2401386. doi: 10.1002/advs.202401386. Epub 2024 Jun 18.

DOI:10.1002/advs.202401386
PMID:38894575
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11336981/
Abstract

Since two-dimensionalal (2D) materials have distinct chemical and physical properties, they are widely used in various sectors of modern technologies. In the domain of diagnostic biodevices, particularly for point-of-care (PoC) biomedical diagnostics, 2D-based field-effect transistor biosensors (bio-FETs) demonstrate substantial potential. Here, in this review article, the operational mechanisms and detection capabilities of biosensing devices utilizing graphene, transition metal dichalcogenides (TMDCs), black phosphorus, and other 2D materials are addressed in detail. The incorporation of these materials into FET-based biosensors offers significant advantages, including low detection limits (LOD), real-time monitoring, label-free diagnosis, and exceptional selectivity. The review also highlights the diverse applications of these biosensors, ranging from conventional to wearable devices, underscoring the versatility of 2D material-based FET devices. Additionally, the review provides a comprehensive assessment of the limitations and challenges faced by these devices, along with insights into future prospects and advancements. Notably, a detailed comparison of FET-based biosensors is tabulated along with various other biosensing platforms and their working mechanisms. Ultimately, this review aims to stimulate further research and innovation in this field while educating the scientific community about the latest advancements in 2D materials-based biosensors.

摘要

由于二维（2D）材料具有独特的化学和物理性质，因此它们被广泛应用于现代技术的各个领域。在诊断生物器件领域，特别是在即时医疗诊断（PoC）生物医学诊断中，基于 2D 的场效应晶体管生物传感器（bio-FET）显示出巨大的潜力。在这篇综述文章中，详细讨论了利用石墨烯、过渡金属二卤化物（TMDC）、黑磷和其他 2D 材料的生物传感器件的工作机制和检测能力。将这些材料纳入基于 FET 的生物传感器具有显著的优势，包括低检测限（LOD）、实时监测、无标记诊断和出色的选择性。本综述还强调了这些生物传感器的各种应用，从传统设备到可穿戴设备，突出了基于 2D 材料 FET 器件的多功能性。此外，本综述还全面评估了这些器件面临的局限性和挑战，并深入探讨了未来的前景和发展。值得注意的是，详细比较了基于 FET 的生物传感器以及其他各种生物传感平台及其工作机制。最终，本综述旨在激发该领域的进一步研究和创新，并为科学界提供有关基于 2D 材料的生物传感器的最新进展的教育。

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