Nishimura Tomoko, Kunieda Kenjiro, Aoyama Kei, Shimomura Takahito, Suzuki Toshio, Inagaki Yoshikazu, Ban Naomi, Nakamura Hideki, Sakamoto Kyoko, Itani Kenji, Nishimura Takefumi, Nakamura Fumiya, Kassai Kyoichi, Ohno Tomohisa, Fujishima Ichiro
Department of Gastroenterology, Nishijin Hospital, Japan.
Department of Neurology, Gifu University Graduate School of Medicine, Japan.
Intern Med. 2025 Jun 15;64(12):1799-1807. doi: 10.2169/internalmedicine.4054-24. Epub 2024 Dec 12.
Objective Gastroesophageal reflux disease (GERD) is a condition characterized by reflux of gastric contents, leading to damage to the esophageal mucosa and/or unpleasant symptoms, with a global prevalence of 13%. Although acid-suppressive medications are currently the most effective treatments for GERD, they may be ineffective against its symptoms. We therefore investigated the efficacy of a physical exercise program for the treatment of intractable GERD symptoms. Methods Fifteen participants who underwent upper gastrointestinal endoscopy were included in this study. They received acid-suppressive drugs for more than eight weeks and had a score of ≥8 on the Frequency Scale for the Symptoms of GERD (FSSG). Participants were instructed to perform a 2-week interventional exercise program comprising drinking saliva 10 times in the bridge position (bridge dry swallowing exercise). This involved swallowing saliva without any food or drink while the hip was raised in the supine position. Changes in the FSSG scores after exercise were examined (UMIN000047829). Results Among the 15 participants, 7 were men, with a median age of 59 years old. Each participant had mild reflux esophagitis or no mucosal injuries. All participants completed the exercise program safely. Of the 15 participants, 13 demonstrated an improvement in the FSSG score after the intervention. The total FSSG score improved significantly from a median of 17 to 11 (p <0.001). Five participants discontinued acid-suppressive drugs after the intervention ended. Conclusions Bridge dry swallowing exercises can improve the intractable symptoms of GERD. However, further studies are required to verify its efficacy and safety.
目的 胃食管反流病(GERD)是一种以胃内容物反流为特征的疾病,可导致食管黏膜损伤和/或出现不适症状,全球患病率为13%。尽管抑酸药物目前是治疗GERD最有效的方法,但它们可能对其症状无效。因此,我们研究了一项体育锻炼计划对治疗难治性GERD症状的疗效。方法 本研究纳入了15名接受上消化道内镜检查的参与者。他们接受了超过8周的抑酸药物治疗,且胃食管反流症状频率量表(FSSG)评分≥8分。参与者被指导进行一项为期2周的干预性锻炼计划,包括在桥式体位下吞咽10次唾液(桥式干吞锻炼)。这包括在仰卧位抬起臀部时,不进食或饮水的情况下吞咽唾液。检查锻炼后FSSG评分的变化(UMIN000047829)。结果 15名参与者中,7名男性,中位年龄59岁。每位参与者均有轻度反流性食管炎或无黏膜损伤。所有参与者均安全完成了锻炼计划。15名参与者中,13名在干预后FSSG评分有所改善。FSSG总分从中位值17分显著提高到11分(p<0.001)。5名参与者在干预结束后停用了抑酸药物。结论 桥式干吞锻炼可改善GERD的难治性症状。然而,需要进一步研究来验证其疗效和安全性。