Batool-Anwar Salma, Fashanu Olabimpe S, Quan Stuart F
Clinic of Sleep and Circadian Disorders, Harvard Medical School, Brigham and Women’s Hospital, Massachusetts, United States of America
Asthma and Airway Disease Research Center, University of Arizona College of Medicine, Arizona, United States of America
Thorac Res Pract. 2025 Jan 3;26(1):9-16. doi: 10.5152/ThoracResPract.2024.24013. Epub 2024 Sep 23.
To examine the long-term impact of Coronavirus disease-2019 (COVID-19) on sleep patterns and the prevalence of sleep disorders and to increase public health awareness of long-term COVID-19.
Using the Massachusetts General Brigham Research Patient Data Registry, Severe acute respiratory syndrome-Coronavirus-2 (SARS-CoV-2) positive patients were surveyed about their sleep patterns before and after the viral infection. Information related to comorbid conditions and medications was obtained through chart review.
Two hundred and forty-six completed surveys were analyzed. Average age was 53.3±16.3 years, and they were predominantly non-hispanic white (84.1%) and female (74.3%). The mean body mass index (kg/m) was 29.9±6.9, and a greater proportion were non-smokers (63.2%). After COVID-19, there was an increase in the percentage of participants reporting difficulty initiating (39±49% vs. 31±46% prior to COVID-19 infection = 0.01). Similarly, the participants reported difficulty in maintaining sleep after COVID infection (57% vs. 43% prior to infection < 0.001). Additionally, there was an increase in the use of sleep aids (30% vs. 24% before the infection = 0.003). The participants also reported a decrease in feeling rested and an increase in the need for napping (58% vs. 36%, < 0.0001) and (27% vs. 40%, < 0.0001) respectively. The sleep symptoms persisted beyond 12 months in 28% of the participants.
SARS-CoV-2 infection had negative effects on sleep, and a significant proportion of adults experienced insomnia and daytime sleepiness beyond 12 months after recovering from the initial infection.
研究2019冠状病毒病（COVID-19）对睡眠模式的长期影响以及睡眠障碍的患病率，并提高公众对长期COVID-19的健康意识。
利用马萨诸塞州综合布莱根研究患者数据登记处，对严重急性呼吸综合征冠状病毒2（SARS-CoV-2）阳性患者在病毒感染前后的睡眠模式进行调查。通过病历审查获取与合并症和药物相关的信息。
分析了246份完整的调查问卷。平均年龄为53.3±16.3岁，主要为非西班牙裔白人（84.1%）和女性（74.3%）。平均体重指数（kg/m）为29.9±6.9，不吸烟者比例更高（63.2%）。感染COVID-19后，报告入睡困难的参与者百分比增加（39±49% vs. COVID-19感染前的31±46% = 0.01）。同样，参与者报告感染COVID后难以维持睡眠（57% vs. 感染前的43% < 0.001）。此外，助眠药物的使用增加（30% vs. 感染前的24% = 0.003）。参与者还报告感觉休息不足的情况增加，小睡需求增加（分别为58% vs. 36%，< 0.0001）和（27% vs. 40%，< 0.0001）。28%的参与者睡眠症状持续超过12个月。
SARS-CoV-2感染对睡眠有负面影响，相当一部分成年人在从初始感染康复12个月后仍经历失眠和日间嗜睡。
