McKenna M J, Freaney R, Meade A, Muldowney F P
Am J Clin Nutr. 1985 Jan;41(1):101-9. doi: 10.1093/ajcn/41.1.101.
The vitamin D status of 181 elderly Irish community-dwelling and institutionalized subjects was studied during Winter-Spring. The mean serum 25-hydroxyvitamin D level was 10 nmol/L (95% range less than 5.0-59 nmol/L); values were below 25 nmol/L in 79 percent of subjects. A significant seasonal variation of serum 25-hydroxyvitamin D levels was noted in elderly community-dwelling subjects. The previously documented age-related increase in serum alkaline phosphatase activity was significantly less in vitamin D replete subjects than in vitamin D deplete subjects in this study (P less than 0.005). The higher serum alkaline phosphatase values found in the vitamin D deplete subjects may represent mild secondary hyperparathyroidism or osteomalacia. The relationship of vitamin D status to both dietary intake and effective sunlight (latitude) is examined.
在冬春季节对181名居住在爱尔兰社区及养老院的老年人的维生素D状况进行了研究。血清25-羟维生素D的平均水平为10纳摩尔/升（95%范围小于5.0至59纳摩尔/升）；79%的受试者该值低于25纳摩尔/升。在居住于社区的老年受试者中，血清25-羟维生素D水平存在显著的季节性变化。在本研究中，先前记录的血清碱性磷酸酶活性随年龄增长的升高在维生素D充足的受试者中显著低于维生素D缺乏的受试者（P<0.005）。维生素D缺乏的受试者中较高的血清碱性磷酸酶值可能代表轻度继发性甲状旁腺功能亢进或骨软化症。研究了维生素D状况与饮食摄入及有效日照（纬度）之间的关系。
