McKinley M, Budman D, Caccese W, Weissman G, Scheidt N, Kahn E, Bronzo R
Am J Gastroenterol. 1985 Jan;80(1):47-9.
Colonoscopy is a valuable and frequently used method in the evaluation of colonic neoplasia. Flow cytometry is a technique that can be used to diagnose malignancy. In this study, flow cytometry was used to evaluate colonoscopic biopsies taken from patients with suspected colonic neoplasia. Nineteen colonic biopsies were obtained and evaluated by this technique. Aneuploidy was demonstrated in six patients with carcinoma of the colon. In addition, abnormal DNA histograms were noted in two premalignant conditions (colonic adenoma and inflammatory bowel disease). The results show that flow cytometry can be applied to colonic biopsies and suggest that it may be of use in the diagnosis of malignant and premalignant conditions of the colon.
结肠镜检查是评估结肠肿瘤的一种有价值且常用的方法。流式细胞术是一种可用于诊断恶性肿瘤的技术。在本研究中，流式细胞术用于评估从疑似结肠肿瘤患者获取的结肠镜活检样本。通过该技术获得并评估了19份结肠活检样本。在6例结肠癌患者中发现了非整倍体。此外，在两种癌前病变（结肠腺瘤和炎症性肠病）中也观察到了异常的DNA直方图。结果表明，流式细胞术可应用于结肠活检，提示其可能在结肠恶性和癌前病变的诊断中发挥作用。
