Human-specific gene -potentially an additional tool in the treatment of neurodegenerative diseases?
作者信息
Huttner Wieland B
机构信息
Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
出版信息
Front Mol Med. 2024 Nov 27;4:1465647. doi: 10.3389/fmmed.2024.1465647. eCollection 2024.
Abstract
摘要
相似文献
1
Human-specific gene -potentially an additional tool in the treatment of neurodegenerative diseases?人类特异性基因——治疗神经退行性疾病的潜在新工具？
Front Mol Med. 2024 Nov 27;4:1465647. doi: 10.3389/fmmed.2024.1465647. eCollection 2024.
2
Human-specific ARHGAP11B ensures human-like basal progenitor levels in hominid cerebral organoids.人类特异性 ARHGAP11B 确保了同源脑细胞类器官中类似人类的基底祖细胞水平。
EMBO Rep. 2022 Nov 7;23(11):e54728. doi: 10.15252/embr.202254728. Epub 2022 Sep 13.
3
Human-Specific ARHGAP11B Acts in Mitochondria to Expand Neocortical Progenitors by Glutaminolysis.人类特异性 ARHGAP11B 通过谷氨酰胺分解作用在线粒体中扩张新皮层祖细胞。
Neuron. 2020 Mar 4;105(5):867-881.e9. doi: 10.1016/j.neuron.2019.11.027. Epub 2019 Dec 26.
4
A single splice site mutation in human-specific causes basal progenitor amplification.人类特异性基因中的一个剪接位点突变导致基底祖细胞扩增。
Sci Adv. 2016 Dec 7;2(12):e1601941. doi: 10.1126/sciadv.1601941. eCollection 2016 Dec.
5
Neocortical neurogenesis in development and evolution-Human-specific features.神经发生在发育和进化中的新皮层-人类特有的特征。
J Comp Neurol. 2024 Feb;532(2):e25576. doi: 10.1002/cne.25576. Epub 2024 Jan 8.
6
Human-specific gene ARHGAP11B promotes basal progenitor amplification and neocortex expansion.人类特异性基因 ARHGAP11B 促进基底祖细胞扩增和新皮层扩张。
Science. 2015 Mar 27;347(6229):1465-70. doi: 10.1126/science.aaa1975. Epub 2015 Feb 26.
7
Generation of a homozygous ARHGAP11B knockout hiPSC line by CRISPR/Cas9 system.利用 CRISPR/Cas9 系统生成纯合性 ARHGAP11B 基因敲除 hiPSC 系。
Stem Cell Res. 2022 May;61:102764. doi: 10.1016/j.scr.2022.102764. Epub 2022 Mar 24.
8
Human-specific increases size and folding of primate neocortex in the fetal marmoset.人类特有的因素增加了胎生狨猴灵长类新皮质的大小和折叠。
Science. 2020 Jul 31;369(6503):546-550. doi: 10.1126/science.abb2401. Epub 2020 Jun 18.
9
Human-specific induces hallmarks of neocortical expansion in developing ferret neocortex.人类特异性 诱导发育中雪貂新皮层的新皮层扩张特征。
Elife. 2018 Nov 28;7:e41241. doi: 10.7554/eLife.41241.
10
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.人类特异性 ARHGAP11B 在小鼠中的表达导致新皮层扩张和记忆灵活性增加。
EMBO J. 2021 Jul 1;40(13):e107093. doi: 10.15252/embj.2020107093. Epub 2021 May 3.
本文引用的文献
1
Neuronal Cell Differentiation of iPSCs for the Clinical Treatment of Neurological Diseases.用于神经疾病临床治疗的诱导多能干细胞的神经元细胞分化
Biomedicines. 2024 Jun 18;12(6):1350. doi: 10.3390/biomedicines12061350.
2
Emerging Pro-neurogenic Therapeutic Strategies for Neurodegenerative Diseases: A Review of Pre-clinical and Clinical Research.神经退行性疾病新兴的促神经发生治疗策略：临床前和临床研究综述
Mol Neurobiol. 2025 Jan;62(1):46-76. doi: 10.1007/s12035-024-04246-w. Epub 2024 May 31.
3
Identity and nature of neural stem cells in the adult human subventricular zone.成体人类脑室下区神经干细胞的特性与本质
iScience. 2024 Feb 27;27(4):109342. doi: 10.1016/j.isci.2024.109342. eCollection 2024 Apr 19.
4
Harnessing the Stem Cell Niche in Regenerative Medicine: Innovative Avenue to Combat Neurodegenerative Diseases.利用再生医学中的干细胞生态位：治疗神经退行性疾病的创新途径。
Int J Mol Sci. 2024 Jan 12;25(2):993. doi: 10.3390/ijms25020993.
5
Neocortical neurogenesis in development and evolution-Human-specific features.神经发生在发育和进化中的新皮层-人类特有的特征。
J Comp Neurol. 2024 Feb;532(2):e25576. doi: 10.1002/cne.25576. Epub 2024 Jan 8.
6
Advancing cell therapy for neurodegenerative diseases.推进神经退行性疾病的细胞疗法。
Cell Stem Cell. 2023 May 4;30(5):512-529. doi: 10.1016/j.stem.2023.03.017. Epub 2023 Apr 20.
7
Evidence for postnatal neurogenesis in the human amygdala.人类杏仁核内存在出生后神经发生的证据。
Commun Biol. 2022 Apr 19;5(1):366. doi: 10.1038/s42003-022-03299-8.
8
Expression of human-specific ARHGAP11B in mice leads to neocortex expansion and increased memory flexibility.人类特异性 ARHGAP11B 在小鼠中的表达导致新皮层扩张和记忆灵活性增加。
EMBO J. 2021 Jul 1;40(13):e107093. doi: 10.15252/embj.2020107093. Epub 2021 May 3.
9
Metabolic Regulation of Neocortical Expansion in Development and Evolution.发育与进化过程中皮质扩张的代谢调控
Neuron. 2021 Feb 3;109(3):408-419. doi: 10.1016/j.neuron.2020.11.014. Epub 2020 Dec 10.
10
Human-specific increases size and folding of primate neocortex in the fetal marmoset.人类特有的因素增加了胎生狨猴灵长类新皮质的大小和折叠。
Science. 2020 Jul 31;369(6503):546-550. doi: 10.1126/science.abb2401. Epub 2020 Jun 18.
Zotero 插件