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从患有角膜炎的CD36基因敲除小鼠（B6.129S1 - /J）眼表分离出的菌株的基因组序列草图。

Draft genome sequences of strains isolated from ocular surface of CD36-knockout mice (B6.129S1-/J) with keratitis.

作者信息

Mannion Anthony, Shen Zeli, Buckley-Jordan Ellen, Garcia Alexis, Lyons Claire, Lee Yao, Boucher Magalie, Carrasco Sebastian, Gilmore Michael S, Fox James G

机构信息

Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA.

Departments of Ophthalmology, and Microbiology and Immunobiology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA.

出版信息

Microbiol Resour Announc. 2025 Jan 16;14(1):e0056224. doi: 10.1128/mra.00562-24. Epub 2024 Dec 12.

DOI:10.1128/mra.00562-24
PMID:39665562
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11737164/
Abstract

Three strains were cultured from the eyes of CD36-knockout mice (B6.129S1-/J) with and without keratitis housed at a biomedical research institute. Bacteria were sequenced using Illumina MiSeq technology for subsequent phylogenetic characterization and identification of virulence factor genes conferring pathogenic potential.

摘要

从一家生物医学研究所饲养的患有和未患有角膜炎的CD36基因敲除小鼠（B6.129S1 - /J）的眼睛中培养出了三株菌株。使用Illumina MiSeq技术对细菌进行测序，以便随后进行系统发育特征分析和鉴定具有致病潜力的毒力因子基因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/11737164/267ddcf79b5f/mra.00562-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/11737164/267ddcf79b5f/mra.00562-24.f001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/756d/11737164/267ddcf79b5f/mra.00562-24.f001.jpg

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Nucleic Acids Res. 2023 Jan 6;51(D1):D678-D689. doi: 10.1093/nar/gkac1003.
2
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VFDB 2022: a general classification scheme for bacterial virulence factors.
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