Omar Shaimaa Ismail, El-Mulla Khaled Fawzy, Eldabah Nermeen, El-Busaidy Aziza
Department of Dermatology, Venereology and Andrology, Faculty of Medicine, Alexandria University, Elkhartoum Square, El Messalah, Alexandria, 21521, Egypt.
Department of Clinical and Chemical Pathology, Faculty of Medicine, Alexandria University, Alexandria, Egypt.
Arch Dermatol Res. 2024 Dec 12;317(1):97. doi: 10.1007/s00403-024-03561-5.
Acne vulgaris, a prevalent inflammatory skin condition, is closely linked to the immune system's regulation and oxidative stress. During Ramadan, the practice of intermittent fasting-abstaining from food and drink from dawn to sunset-can impact both body and skin health, potentially influencing the pathophysiology of acne including the immune response and the oxidative status. The objective of this study was to investigate the impact of Ramadan fasting on disease severity, Th1/Th17 cytokine levels, and oxidative status in patients with acne vulgaris.
The study involved 40 patients with acne vulgaris. The severity of the condition was evaluated using the Global Acne grading System (GAGS) score, body mass index (BMI) was calculated, and levels of interleukin (IL-17), interferon gamma (IFN-γ), and Malondialdehyde (MDA) were measured both before and after the fasting period.
A significant reduction in GAGS score, IL-17, IFN-γ, and MDA levels was observed after Ramadan fasting compared to before Ramadan. Additionally, the percentage decrease in GAGS score showed a positive correlation with the percentage decrease in IFN-γ.
Intermittent fasting during Ramadan could potentially benefit acne vulgaris by reducing the Th1/Th17 immune response and lowering oxidative stress.
寻常痤疮是一种常见的炎症性皮肤病，与免疫系统调节和氧化应激密切相关。在斋月期间，实行间歇性禁食（从黎明到日落禁食食物和饮料）会影响身体和皮肤健康，可能影响痤疮的病理生理学，包括免疫反应和氧化状态。本研究的目的是调查斋月禁食对寻常痤疮患者疾病严重程度、Th1/Th17细胞因子水平和氧化状态的影响。
该研究纳入了40例寻常痤疮患者。使用全球痤疮分级系统（GAGS）评分评估病情严重程度，计算体重指数（BMI），并在禁食期前后测量白细胞介素（IL-17）、干扰素γ（IFN-γ）和丙二醛（MDA）水平。
与斋月前相比，斋月禁食后GAGS评分、IL-17、IFN-γ和MDA水平显著降低。此外，GAGS评分的下降百分比与IFN-γ的下降百分比呈正相关。
斋月期间的间歇性禁食可能通过降低Th1/Th17免疫反应和减轻氧化应激而对寻常痤疮有益。
