衰老对胰腺消化酶的影响。

Influence of aging upon pancreatic digestive enzymes.

作者信息

Greenberg R E, Holt P R

出版信息

Dig Dis Sci. 1986 Sep;31(9):970-7. doi: 10.1007/BF01303218.

Abstract

The effects of aging upon pancreatic digestive enzymes were studied in 27- and 3-month-old Fischer 344 rats. Mean pancreatic weight, protein and DNA concentration and content, and protein-DNA ratios did not differ in the two groups of animals. Pancreatic amylase concentration was reduced by 41% and lipase concentration was increased by 29% in the aging animals, whereas, trypsinogen concentrations did not differ. Young and aging rats were fed diets enriched with fat (72%) or sucrose (75%) for seven days to define whether the different enzyme contents were intrinsic to the aging process or adaptable. In young, but not in aging rats, lipase concentration increased 25% during high fat compared to high sucrose diet feeding. High starch diet feeding induced a 26% increase in amylase in young rats but not in the old. Trypsinogen concentration was unaffected by dietary manipulation. Jejunal enteropeptidase concentration was modestly reduced in the aging rat. Postprandial luminal concentrations of trypsin and amylase did not differ in the two groups. Thus, aging may induce modest changes in pancreatic digestive enzymes and in jejunal enteropeptidase which are unlikely to be physiologically important. However, the pancreas of aging rats does not adapt to changes in dietary intake as well as young rats.

摘要

在27月龄和3月龄的Fischer 344大鼠中研究了衰老对胰腺消化酶的影响。两组动物的胰腺平均重量、蛋白质和DNA浓度及含量，以及蛋白质-DNA比率均无差异。衰老动物的胰腺淀粉酶浓度降低了41%，脂肪酶浓度增加了29%，而胰蛋白酶原浓度没有差异。给年轻和衰老大鼠喂食富含脂肪（72%）或蔗糖（75%）的饲料7天，以确定不同的酶含量是衰老过程所固有的还是可适应的。在年轻大鼠中，与高蔗糖饮食喂养相比，高脂肪饮食喂养期间脂肪酶浓度增加了25%，但衰老大鼠没有这种变化。高淀粉饮食喂养使年轻大鼠的淀粉酶增加了26%，但老年大鼠没有。胰蛋白酶原浓度不受饮食操作的影响。衰老大鼠空肠肠肽酶浓度略有降低。两组的餐后肠腔胰蛋白酶和淀粉酶浓度没有差异。因此，衰老可能会引起胰腺消化酶和空肠肠肽酶的适度变化，而这些变化在生理上可能并不重要。然而，衰老大鼠的胰腺对饮食摄入变化的适应能力不如年轻大鼠。