Hsu Chou-Yi, Pallathadka Harikumar, Jasim Saade Abdalkareem, Rizaev Jasur, Olegovich Bokov Dmitry, Hjazi Ahmed, Mahajan Shriya, Mustafa Yasser Fakri, Husseen Beneen, Jawad Mohammed Abed
Thunderbird School of Global Management, Arizona State University Tempe Campus, Phoenix, AZ 85004, USA.
Manipur International University, Imphal, Manipur, India.
Crit Rev Oncol Hematol. 2025 Feb;206:104588. doi: 10.1016/j.critrevonc.2024.104588. Epub 2024 Dec 10.
A major advance in cancer treatment has been the development and refinement of cancer immunotherapy. The discovery of immunotherapies for a wide range of cancers has revolutionized cancer treatment paradigms. Despite relapse or refractory disease, immunotherapy approaches can prolong the life expectancy of metastatic cancer patients. Multiple therapeutic approaches and agents are currently being developed to manipulate various aspects of the immune system. Oncolytic viruses, cancer vaccines, adoptive cell therapies, monoclonal antibodies, cytokine therapies, and inhibitors of immune checkpoints have all proven successful in clinical trials. There are several types of immunotherapeutic approaches available for treating cancer, and others are being tested in preclinical and clinical settings. Immunotherapy has proven successful, and many agents and strategies have been developed to improve its effectiveness. The purpose of this article is to present a comprehensive overview of current immunotherapy approaches used to treat cancer. Cancer immunotherapy advancements, emerging patterns, constraints, and potential future breakthroughs are also discussed.
癌症治疗的一项重大进展是癌症免疫疗法的发展与完善。针对多种癌症的免疫疗法的发现彻底改变了癌症治疗模式。尽管存在复发或难治性疾病，但免疫疗法可延长转移性癌症患者的预期寿命。目前正在研发多种治疗方法和药物来调控免疫系统的各个方面。溶瘤病毒、癌症疫苗、过继性细胞疗法、单克隆抗体、细胞因子疗法以及免疫检查点抑制剂在临床试验中均已证明取得成功。有几种免疫治疗方法可用于治疗癌症，其他方法正在临床前和临床环境中进行测试。免疫疗法已被证明是成功的，并且已经开发了许多药物和策略来提高其有效性。本文旨在全面概述目前用于治疗癌症的免疫疗法。还讨论了癌症免疫疗法的进展、新出现的模式、限制因素以及未来可能的突破。
