Askari Fizza, Kaur Rupinder
BRIC-Centre for DNA Fingerprinting and Diagnostics (CDFD), Hyderabad 500039, India.
ACS Infect Dis. 2025 Jan 10;11(1):4-20. doi: 10.1021/acsinfecdis.4c00477. Epub 2024 Dec 13.
() , an opportunistic human fungal pathogen, causes mucosal and deep-seated infections in immunocompromised individuals. Recently designated as a high-priority fungal pathogen by the World Health Organization (WHO), exhibits low inherent susceptibility to azole antifungals. In addition, about 10% clinical isolates of display co-resistance to both azole and echinocandin drugs. Molecular mechanisms of antifungal resistance and virulence in are currently being delineated in-depth. This Review provides an overview of the epidemiology, biology, drug resistance, tools and host model systems for . Additionally, we discuss the immune evasion strategies that aid in establishing infections in the host. Overall, this Review aims to contribute to ongoing efforts to raise awareness of human pathogenic fungi, the growing threat of antifungal drug resistance and the unmet need for novel antifungal therapies, with an ultimate goal of improving clinical outcomes of affected individuals.
（）是一种机会性人类真菌病原体，可在免疫功能低下的个体中引起黏膜和深部感染。最近被世界卫生组织（WHO）指定为高优先级真菌病原体，对唑类抗真菌药物表现出较低的固有敏感性。此外，约10%的临床分离株对唑类和棘白菌素类药物均表现出交叉耐药性。目前正在深入研究（）中抗真菌耐药性和毒力的分子机制。本综述概述了（）的流行病学、生物学、耐药性、研究工具和宿主模型系统。此外，我们还讨论了有助于（）在宿主体内建立感染的免疫逃避策略。总体而言，本综述旨在促进当前提高对人类致病真菌的认识、抗真菌耐药性日益增长的威胁以及新型抗真菌疗法未满足需求的努力，最终目标是改善受影响个体的临床结局。
