Laboratory of Fungal Pathogenesis, Centre for DNA Fingerprinting and Diagnostics , Hyderabad, India.
Graduate Studies, Manipal Academy of Higher Education , Manipal, India.
Expert Rev Anti Infect Ther. 2020 Nov;18(11):1093-1103. doi: 10.1080/14787210.2020.1792773. Epub 2020 Jul 15.
The opportunistic fungal pathogen poses a clinical challenge in the successful treatment of invasive infections, owing to its low inherent susceptibility toward azole antifungals and the recent acquisition of coresistance toward azole and echinocandin drugs. Compared to other prevalent bloodstream pathogens, neither exhibits secreted proteolytic activity nor invokes a strong immune response in a variety of host cells and is less virulent. It also does not form true hyphae, and the success of , therefore, as a prevalent human fungal pathogen, appears to be built upon a distinct set of virulence attributes.
The focus of this review is to outline, in brief, the interaction of with the host, deduced from the knowledge gained from different and model systems. In addition, we briefly discuss the current antifungals, antifungal resistance mechanisms, and the development of new antifungal therapies, along with the available information on the host response.
A detailed understanding of stresses, selection pressures and differential immune responses in the presence and absence of antifungals that encounters in varied niches of the host, is required to design effective antifungal therapy.
机会性真菌病原体 由于其对唑类抗真菌药物的固有低敏感性以及最近对唑类和棘白菌素药物的获得性耐药性，给侵袭性 感染的成功治疗带来了临床挑战。与其他常见的 血流感染病原体相比， 既没有表现出分泌蛋白水解活性，也没有在各种宿主细胞中引发强烈的免疫反应，其毒力也较低。它也不形成真正的菌丝，因此 作为一种常见的人类真菌病原体的成功似乎是建立在一套独特的毒力特征基础上的。
这篇综述的重点是简要概述从不同 和 模型系统中获得的知识，推断 与宿主的相互作用。此外，我们还简要讨论了当前的抗真菌药物、抗真菌耐药机制以及新的抗真菌治疗方法的发展，以及宿主反应的现有信息。
为了设计有效的抗真菌治疗方法，需要详细了解 在宿主不同生态位中遇到的压力、选择压力和有无抗真菌药物时的差异免疫反应。
