Tong Ying, Gao Meng, Luo Yingli
Wuxi School of Medicine, Jiangnan University, Wuxi 214122, Jiangsu, China.
State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China.
IET Nanobiotechnol. 2024 Dec 5;2024:1069307. doi: 10.1049/nbt2/1069307. eCollection 2024.
Mesenchymal stem cell (MSC) membrane-coated metal-organic frameworks (MOFs) represent an innovative approach to enhance the uptake and therapeutic efficacy of copper-based MOFs (Cu-MOFs) in tumor cells. By leveraging the natural homing abilities and biocompatibility of MSC membranes, Cu-MOFs can be effectively targeted to tumor sites, promoting increased cellular uptake. This coating not only facilitates superior internalization by cancer cells but also augments the therapeutic outcomes due to the enhanced delivery of copper ions. In vitro studies demonstrate that MSC membrane-coated Cu-MOFs (MSC-Cu-MOFs) significantly improve the cytotoxic effects on tumor cells compared to uncoated Cu-MOFs. This novel strategy presents a promising avenue for advancing the precision and effectiveness of cancer treatment modalities, showcasing potential for clinical applications in oncology.
间充质干细胞（MSC）膜包被的金属有机框架（MOF）是一种创新方法，可增强铜基MOF（Cu-MOF）在肿瘤细胞中的摄取和治疗效果。通过利用MSC膜的天然归巢能力和生物相容性，Cu-MOF可以有效地靶向肿瘤部位，促进细胞摄取增加。这种包被不仅有助于癌细胞更好地内化，还由于铜离子的递送增强而提高了治疗效果。体外研究表明，与未包被的Cu-MOF相比，MSC膜包被的Cu-MOF（MSC-Cu-MOF）显著提高了对肿瘤细胞的细胞毒性作用。这种新策略为提高癌症治疗方式的精准性和有效性提供了一条有前景的途径，展示了在肿瘤学临床应用中的潜力。
