Li Jianzhao, Lin Yuning
Department of Orthopaedics, The first people's hospital of Zhaoqing, Zhaoqing, China.
Front Endocrinol (Lausanne). 2024 Nov 28;15:1461961. doi: 10.3389/fendo.2024.1461961. eCollection 2024.
Remnant cholesterol (RC) is a novel lipid metabolism indicator; however, its relationship with sarcopenia has not been clearly established. This study was conducted to explore the association between RC and sarcopenia.
An analysis was performed utilizing cross-sectional data from the NHANES 2011-2018. The variable RC was subjected to a logarithmic transformation to address its skewness. Logistic regression studies were conducted to examine the association between RC and sarcopenia. This study used restricted cubic spline (RCS) and threshold saturation techniques to investigate nonlinear connections. Subgroup, sensitivity, and additional analyses were performed to assess the robustness and validity of the findings.
The study included 4636 participants. Participants with sarcopenia had significantly higher RC levels. Logistic regression demonstrated a substantial positive association between the prevalence of sarcopenia and log RC (OR=1.69, 95% CI=1.32-2.17). RCS analysis revealed a nonlinear relationship, identifying a threshold at RC=25. When the RC is below this threshold, every one-unit increase in RC increases the chance of sarcopenia by 7% (OR=1.07, 95% CI=1.04-1.10); above this threshold, changes in RC were not significant. Subgroup analysis confirmed that RC was an independent risk factor for sarcopenia. The sensitivity and supplementary analyses supported the main findings.
This study demonstrates a significant positive association between RC levels and the prevalence of sarcopenia in U.S. adults, offering novel evidence that RC may serve as a valuable indicator for sarcopenia assessment.
残余胆固醇（RC）是一种新型脂质代谢指标；然而，其与肌肉减少症的关系尚未明确确立。本研究旨在探讨RC与肌肉减少症之间的关联。
利用2011 - 2018年美国国家健康与营养检查调查（NHANES）的横断面数据进行分析。对变量RC进行对数变换以解决其偏态性。进行逻辑回归研究以检验RC与肌肉减少症之间的关联。本研究使用受限立方样条（RCS）和阈值饱和技术来研究非线性关系。进行亚组、敏感性和额外分析以评估研究结果的稳健性和有效性。
该研究纳入了4636名参与者。患有肌肉减少症的参与者RC水平显著更高。逻辑回归显示肌肉减少症患病率与log RC之间存在显著正相关（OR = 1.69，95% CI = 1.32 - 2.17）。RCS分析揭示了一种非线性关系，确定RC = 25时为阈值。当RC低于此阈值时，RC每增加一个单位，肌肉减少症的发生几率增加7%（OR = 1.07，95% CI = 1.04 - 1.10）；高于此阈值时，RC的变化不显著。亚组分析证实RC是肌肉减少症的独立危险因素。敏感性和补充分析支持了主要研究结果。
本研究表明美国成年人中RC水平与肌肉减少症患病率之间存在显著正相关，提供了新的证据表明RC可能作为评估肌肉减少症的有价值指标。
