Medical College, Qingdao University, Qingdao, 266000, China.
School of Athletic Performance, Shanghai University of Sport, Shanghai, 200438, China.
Sci Rep. 2024 Oct 15;14(1):24126. doi: 10.1038/s41598-024-75873-5.
The triglyceride glucose (TyG) related index, a metric used to evaluate assessing insulin resistance (IR), has received limited attention in its association with sarcopenia. Our study aims to explore the predictive potential of the TyG index for sarcopenia. This study utilized data from the China Health and Retirement Longitudinal Study, a nationally representative, community-based cohort study, including a sample size of 10,537 participants aged 45 years and older. Associations between TyG related index and sacopenia was explored using multivariate logistic regression. Analysis of the predictive value of TyG related index for sarcopenia using receiver-operating characteristic curve (ROC). We evaluated the correlation between the TyG related index and the risk of sarcopenia using Cox proportional hazards models. Additionally, we utilized restricted cubic spline (RCS) regression analyses to explore the connections between the TyG-related index and sarcopenia. Logistic regression analysis showed an association between TyG (OR 0.961[0.955,0.968], P < 0.001), TyG-body mass index (TyG-BMI) (OR 0.872[0.867,0.878], P < 0.001), TyG- waist circumference (TyG-WC) (OR 0.896[0.890,0.902], P < 0.001) and sarcopenia. The results of the ROC analysis indicated that the area under the curve values for TyG, TyG-BMI, and TyG-WC were 0.659, 0.903, and 0.819, respectively. Compared to those without sarcopenia, patients with sarcopenia had a 37.7% (HR 0.623[0.502,0.774], P < 0.001), 4.8% (HR 0.952[0.947,0.958], P < 0.001), and 0.4% (HR 0.996[0.995,0.996], P < 0.001) lower risk with increasing TyG, TyG-BMI, and TyG-WC, respectively. RCS results show nonlinear relationship between TyG-BMI (P < 0.001) and TyG-WC (P < 0.001) and risk of sarcopenia. We observed a correlation between the TyG-related index and sarcopenia, with the TyG-BMI index demonstrating strong predictive capability for sarcopenia.
甘油三酯-葡萄糖（TyG）相关指数是评估胰岛素抵抗（IR）的指标，但其与肌肉减少症的相关性研究较少。本研究旨在探讨 TyG 指数对肌肉减少症的预测价值。本研究利用中国健康与退休纵向研究（China Health and Retirement Longitudinal Study）的数据，该研究是一项全国代表性的社区为基础的队列研究，共纳入了 10537 名年龄在 45 岁及以上的参与者。采用多变量 logistic 回归分析 TyG 相关指数与肌肉减少症的相关性。采用受试者工作特征曲线（receiver operating characteristic curve，ROC）分析 TyG 相关指数对肌肉减少症的预测价值。采用 Cox 比例风险模型评估 TyG 相关指数与肌肉减少症风险的相关性。同时，采用受限立方样条（restricted cubic spline，RCS）回归分析 TyG 相关指数与肌肉减少症的关系。Logistic 回归分析显示，TyG（OR 0.961[0.955,0.968]，P<0.001）、TyG-体重指数（TyG-BMI）（OR 0.872[0.867,0.878]，P<0.001）、TyG-腰围（TyG-WC）（OR 0.896[0.890,0.902]，P<0.001）与肌肉减少症相关。ROC 分析结果表明，TyG、TyG-BMI 和 TyG-WC 的曲线下面积值分别为 0.659、0.903 和 0.819。与无肌肉减少症患者相比，有肌肉减少症患者的风险分别降低 37.7%（HR 0.623[0.502,0.774]，P<0.001）、4.8%（HR 0.952[0.947,0.958]，P<0.001）和 0.4%（HR 0.996[0.995,0.996]，P<0.001）。RCS 结果显示 TyG-BMI（P<0.001）和 TyG-WC（P<0.001）与肌肉减少症风险之间存在非线性关系。我们观察到 TyG 相关指数与肌肉减少症之间存在相关性，其中 TyG-BMI 指数对肌肉减少症具有较强的预测能力。
