一种针对皮质抑素A的氧化去芳构化环化模型。
AN OXIDATIVE DEAROMATIZATION CYCLIZATION MODEL FOR CORTISTATIN A.
作者信息
Dai Mingji, Danishefsky Samuel J
机构信息
Department of Chemistry, Columbia University, 3000 Broadway, New York, NY 10027.
Laboratory for Bioorganic Chemistry, Sloan-Kettering Institute for Cancer Research, 1275 York Ave., New York, NY 10065 (USA).
出版信息
Heterocycles. 2009;77(1):157-161. doi: 10.3987/com-08-s(f)6. Epub 2008 Apr 17.
Abstract
The feasibility of a hypervalent iodine-mediated oxidative dearomatization/cyclization to produce the oxabicyclo[3.2.1]octene of cortistatin A has been demonstrated through a model study. An interesting tandem cyclization via a Ritter intermediate has been observed when a slightly different substrate was used.
摘要
通过模型研究证明了高价碘介导的氧化去芳构化/环化反应生成皮质抑素A的氧杂双环[3.2.1]辛烯的可行性。当使用略有不同的底物时，观察到了经由里特中间体的有趣串联环化反应。
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