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胰腺混合性浆液性神经内分泌肿瘤治疗后副肿瘤性掌跖角化病消退：一例报告及文献复习

Resolution of paraneoplastic palmoplantar keratoderma after treating mixed serous neuroendocrine tumor of the pancreas: a case report and literature review.

作者信息

Alotaibi Hend M, Alluhaybi Abdulrahman, Nagshabandi Khalid Nabil, Barakeh Maha M

机构信息

Department of Dermatology, College of Medicine, King Saud University, Riyadh, Saudi Arabia.

出版信息

Dermatol Reports. 2024 Feb 6;16(4):9906. doi: 10.4081/dr.2024.9906. eCollection 2024 Nov 21.

DOI:10.4081/dr.2024.9906
PMID:39669879
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11632448/
Abstract

Palmoplantar keratodermas (PPKs), also known as 'keratosis palmaris et plantaris', are a heterogeneous group of disorders characterized by abnormal thickening of the epidermal skin of the palms and soles leading to hyperkeratosis. It could be acquired or hereditary. Acquired PPK often occurs as a paraneoplastic syndrome as well as a stigma of other dermatoses. We report a rare case of paraneoplastic PPK secondary to mixed neuroendocrine tumor of the pancreas with complete remission after surgical excision of the cancer.

摘要

掌跖角化病（PPK），也称为“掌跖角化症”，是一组异质性疾病，其特征是手掌和脚底的表皮皮肤异常增厚，导致角化过度。它可以是后天获得性的或遗传性的。后天获得性PPK常作为副肿瘤综合征以及其他皮肤病的一种体征出现。我们报告了一例罕见的胰腺混合性神经内分泌肿瘤继发的副肿瘤性PPK，在癌症手术切除后完全缓解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/e33a1059ed95/dr-16-4-9906-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/94dbbe28f012/dr-16-4-9906-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/b2358104b630/dr-16-4-9906-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/4813313ff344/dr-16-4-9906-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/cde6df33b83d/dr-16-4-9906-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/3782cf8554b8/dr-16-4-9906-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/e33a1059ed95/dr-16-4-9906-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/94dbbe28f012/dr-16-4-9906-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/b2358104b630/dr-16-4-9906-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/4813313ff344/dr-16-4-9906-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/cde6df33b83d/dr-16-4-9906-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/3782cf8554b8/dr-16-4-9906-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ba7/11632448/e33a1059ed95/dr-16-4-9906-g006.jpg

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本文引用的文献

1
Therapeutic experience of a pancreatic mixed serous neuroendocrine neoplasm invading peripancreatic vessels: A case report.胰周血管受侵的胰腺混合性浆液-神经内分泌肿瘤的治疗体会：1 例报告
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Presentation and outcome of mixed neuroendocrine non-neuroendocrine neoplasms of the pancreas.胰腺混合性神经内分泌-非神经内分泌肿瘤的临床表现及转归
Pancreatology. 2021 Jan;21(1):224-235. doi: 10.1016/j.pan.2020.11.020. Epub 2020 Dec 3.
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Cytokinocytes: the diverse contribution of keratinocytes to immune responses in skin.
细胞因子：角质形成细胞对皮肤免疫反应的多样贡献。
JCI Insight. 2020 Oct 15;5(20):142067. doi: 10.1172/jci.insight.142067.
4
Tripe Palms and Acanthosis Nigricans: A Clue for Diagnosis of Advanced Pancreatic Adenocarcinoma.掌跖角化症与黑棘皮病：诊断晚期胰腺腺癌的线索
Indian Dermatol Online J. 2019 Jul-Aug;10(4):453-455. doi: 10.4103/idoj.IDOJ_427_18.
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Mixed serous neuroendocrine neoplasm of the pancreas: Case report and literature review.胰腺混合性浆液性神经内分泌肿瘤：病例报告及文献综述
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Plantar keratoderma as a presenting sign of pancreatic adenocarcinoma.足底角化病作为胰腺腺癌的首发症状。
J Clin Ultrasound. 2008 Feb;36(2):108-9. doi: 10.1002/jcu.20377.
7
Acquired palmoplantar keratoderma.获得性掌跖角化病。
Am J Clin Dermatol. 2007;8(1):1-11. doi: 10.2165/00128071-200708010-00001.
8
Malignant acanthosis nigricans and tripe palms associated with pancreatic adenocarcinoma.与胰腺腺癌相关的恶性黑棘皮病和掌跖角化病。
Cutis. 2006 Jul;78(1):37-40.
9
Cystic neoplasms of the pancreas.胰腺囊性肿瘤
N Engl J Med. 2004 Sep 16;351(12):1218-26. doi: 10.1056/NEJMra031623.
10
Oral acanthosis nigricans, tripe palms and sign of leser-trélat in a patient with gastric adenocarcinoma.一名胃腺癌患者出现口腔黑棘皮病、掌跖角化病和Leser-Trélat征。
Int J Dermatol. 2004 Jul;43(7):530-2. doi: 10.1111/j.1365-4632.2004.02159.x.