• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

用于生产可固化微滴的3D流动聚焦微流体的增材制造。

Additive manufacturing of 3D flow-focusing millifluidics for the production of curable microdroplets.

作者信息

Saleem Muhammad Saeed, Chan Timothy T K, Versluis Michel, Krug Dominik, Lajoinie Guillaume

机构信息

Physics of Fluids Group, Max Planck University of Twente Center for Complex Fluid Dynamics, University of Twente P.O. Box 217 7500 AE Enschede The Netherlands

J. M. Burgers Centre for Fluids Dynamics, University of Twente P.O. Box 217 7500 AE Enschede The Netherlands.

出版信息

RSC Adv. 2024 Dec 12;14(53):39276-39284. doi: 10.1039/d4ra07234k. eCollection 2024 Dec 10.

DOI:10.1039/d4ra07234k
PMID:39670164
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11635350/
Abstract

Microfluidics plays a crucial role in the generation of mono-sized microdroplet emulsions. Traditional glass microfluidic chips typically lack versatility in generating curable droplets of arbitrary liquids due to the inherent hydrophilic nature of glass and to fabrication constraints. To overcome this, we designed a microdroplet generator with 3D flow-focusing capabilities that can be 3D-printed. The chip can handle oil-in-water emulsions despite its lipophilicity. Operating in the jetting regime, the chip exploits the Rayleigh-Plateau instability to enable high throughput. With its versatile design, the chip is capable of producing both single and double emulsions within the same channel. We utilize a thermoset (epoxy-melamine) based system to test its ability to handle curable chemicals and to produce in a post-processing step both solid particles and filled capsules. With a low solvent concentration in the curable material, the present system can encapsulate water-based cores of a wide range of sizes.

摘要

微流控技术在单尺寸微滴乳液的生成中起着至关重要的作用。传统的玻璃微流控芯片由于玻璃固有的亲水性和制造限制，在生成任意液体的可固化液滴方面通常缺乏通用性。为了克服这一问题，我们设计了一种具有三维流动聚焦能力的微滴发生器，该发生器可以通过3D打印制造。尽管该芯片具有亲脂性，但它能够处理水包油乳液。在喷射模式下运行时，该芯片利用瑞利-普拉托不稳定性实现高通量。凭借其通用的设计，该芯片能够在同一通道内产生单乳液和双乳液。我们利用基于热固性材料（环氧三聚氰胺）的系统来测试其处理可固化化学品的能力，并在后期处理步骤中生产固体颗粒和填充胶囊。由于可固化材料中的溶剂浓度较低，本系统可以封装各种尺寸的水基芯材。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/9945a28ed5d1/d4ra07234k-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/a3f140c73956/d4ra07234k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/6daa39742e5a/d4ra07234k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/7eef2bc57654/d4ra07234k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/b466587c8eaa/d4ra07234k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/86a243656164/d4ra07234k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/81ffd4c29885/d4ra07234k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/6ca1c671498b/d4ra07234k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/bf70829c3141/d4ra07234k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/2b9601e9a98f/d4ra07234k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/9945a28ed5d1/d4ra07234k-f10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/a3f140c73956/d4ra07234k-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/6daa39742e5a/d4ra07234k-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/7eef2bc57654/d4ra07234k-f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/b466587c8eaa/d4ra07234k-f4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/86a243656164/d4ra07234k-f5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/81ffd4c29885/d4ra07234k-f6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/6ca1c671498b/d4ra07234k-f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/bf70829c3141/d4ra07234k-f8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/2b9601e9a98f/d4ra07234k-f9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/d972/11635350/9945a28ed5d1/d4ra07234k-f10.jpg

相似文献

1
Additive manufacturing of 3D flow-focusing millifluidics for the production of curable microdroplets.用于生产可固化微滴的3D流动聚焦微流体的增材制造。
RSC Adv. 2024 Dec 12;14(53):39276-39284. doi: 10.1039/d4ra07234k. eCollection 2024 Dec 10.
2
High-Throughput, Off-Chip Microdroplet Generator Enabled by a Spinning Conical Frustum.高通量、片外微滴生成器由旋转的截头圆锥体实现。
Anal Chem. 2019 Mar 5;91(5):3725-3732. doi: 10.1021/acs.analchem.9b00093. Epub 2019 Feb 21.
3
Microneedle-assisted microfluidic flow focusing for versatile and high throughput water-in-water droplet generation.用于多功能高通量水包水液滴生成的微针辅助微流控流动聚焦
J Colloid Interface Sci. 2019 Oct 1;553:382-389. doi: 10.1016/j.jcis.2019.05.100. Epub 2019 May 30.
4
High throughput single-cell and multiple-cell micro-encapsulation.高通量单细胞和多细胞微囊化
J Vis Exp. 2012 Jun 15(64):e4096. doi: 10.3791/4096.
5
In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.气液微流控技术可实现乳液、悬浮液和 3D 模块化（生物）材料的快速制造。
Sci Adv. 2018 Jan 31;4(1):eaao1175. doi: 10.1126/sciadv.aao1175. eCollection 2018 Jan.
6
Additive manufacturing of three-dimensional (3D) microfluidic-based microelectromechanical systems (MEMS) for acoustofluidic applications.基于三维（3D）微流控的微机电系统（MEMS）的增材制造在声流控应用中的研究进展
Lab Chip. 2018 Jul 10;18(14):2087-2098. doi: 10.1039/c8lc00427g.
7
Glass Microdroplet Generator for Lipid-Based Double Emulsion Production.用于生产脂质基双重乳液的玻璃微滴发生器
Micromachines (Basel). 2024 Apr 5;15(4):500. doi: 10.3390/mi15040500.
8
High-Throughput Production of Micrometer Sized Double Emulsions and Microgel Capsules in Parallelized 3D Printed Microfluidic Devices.在并行3D打印微流控装置中高通量生产微米级双乳液和微凝胶胶囊
Polymers (Basel). 2019 Nov 15;11(11):1887. doi: 10.3390/polym11111887.
9
A versatile and robust microfluidic device for capillary-sized simple or multiple emulsions production.一种用于生产毛细管尺寸的单乳液或多乳液的多功能且坚固的微流控装置。
Biomed Microdevices. 2018 Oct 30;20(4):94. doi: 10.1007/s10544-018-0340-2.
10
[Rapid generation of double-layer emulsion droplets based on microfluidic chip].基于微流控芯片的双层乳液微滴快速生成
Sheng Wu Gong Cheng Xue Bao. 2020 Jul 25;36(7):1405-1413. doi: 10.13345/j.cjb.190525.

本文引用的文献

1
Encapsulation with Natural Polymers to Improve the Properties of Biostimulants in Agriculture.用天然聚合物进行包封以改善农业中生物刺激剂的性能。
Plants (Basel). 2022 Dec 22;12(1):55. doi: 10.3390/plants12010055.
2
Microfluidic droplet generation based on non-embedded co-flow-focusing using 3D printed nozzle.基于使用3D打印喷嘴的非嵌入式共流聚焦的微流控液滴生成
Sci Rep. 2020 Dec 10;10(1):21616. doi: 10.1038/s41598-020-77836-y.
3
3D Printed Microfluidics.3D打印微流控技术
Annu Rev Anal Chem (Palo Alto Calif). 2020 Jun 12;13(1):45-65. doi: 10.1146/annurev-anchem-091619-102649. Epub 2019 Dec 10.
4
Capillary-Based Microfluidics-Coflow, Flow-Focusing, Electro-Coflow, Drops, Jets, and Instabilities.基于毛细管的微流控 - 共流，流聚焦，电共流，液滴，射流和不稳定性。
Small. 2020 Mar;16(9):e1904344. doi: 10.1002/smll.201904344. Epub 2019 Oct 30.
5
Laser-activated microparticles for multimodal imaging: ultrasound and photoacoustics.激光激活的多模式成像微粒子：超声和光声。
Phys Med Biol. 2019 Jan 29;64(3):034001. doi: 10.1088/1361-6560/aaf4a2.
6
In-air microfluidics enables rapid fabrication of emulsions, suspensions, and 3D modular (bio)materials.气液微流控技术可实现乳液、悬浮液和 3D 模块化（生物）材料的快速制造。
Sci Adv. 2018 Jan 31;4(1):eaao1175. doi: 10.1126/sciadv.aao1175. eCollection 2018 Jan.
7
Laser-Activated Polymeric Microcapsules for Ultrasound Imaging and Therapy: In Vitro Feasibility.用于超声成像与治疗的激光激活聚合物微胶囊：体外可行性
Biophys J. 2017 May 9;112(9):1894-1907. doi: 10.1016/j.bpj.2017.03.033.
8
3D-printed microfluidic devices.3D 打印微流控器件。
Biofabrication. 2016 Jun 20;8(2):022001. doi: 10.1088/1758-5090/8/2/022001.
9
Discrete elements for 3D microfluidics.用于三维微流体的离散元件。
Proc Natl Acad Sci U S A. 2014 Oct 21;111(42):15013-8. doi: 10.1073/pnas.1414764111. Epub 2014 Sep 22.
10
Cost-effective three-dimensional printing of visibly transparent microchips within minutes.数分钟内以经济高效的方式3D打印出明显透明的微芯片。
Anal Chem. 2014 Mar 18;86(6):3124-30. doi: 10.1021/ac4041857. Epub 2014 Feb 24.