Zhang Yao, Zhu Yeyuhan, Deng Tian, Du Yangge
State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology; Medical Research Institute, School of Medicine, Wuhan University, Wuhan, 430071, People's Republic of China.
Int J Nanomedicine. 2024 Dec 8;19:13201-13216. doi: 10.2147/IJN.S492759. eCollection 2024.
As popular materials, organic room-temperature phosphorescent (RTP) materials have been studied and developed in many fields. RTP materials have the characteristics of a high signal-to-noise ratio (SNR) and high reactive oxygen species (ROS) quantum yield, which can achieve clear bioimaging and efficient ability of anti-tumor and antibacterial, and have received extensive attention from researchers for imaging, tumor therapy, and antibacterial treatment. Moreover, owing to their flexible molecular structures and various synthesis systems and methods, it may be possible to design and synthesize materials according to individual physiologic environments of patients in medical applications, making bioimaging more accurate and greatly improving tumor and bacterial killing rates. So they have great development potential in the medical field. On the basis of introducing the mechanism of RTP materials that emit phosphorescence and generate ROS, this review summarizes the medical applications of RTP materials from three aspects-bioimaging, tumor treatment and antibacterial treatment-to provide a basis for their application in the field of stomatology.
作为热门材料,有机室温磷光(RTP)材料已在许多领域得到研究和开发。RTP材料具有高信噪比(SNR)和高活性氧(ROS)量子产率的特点,能够实现清晰的生物成像以及高效的抗肿瘤和抗菌能力,在成像、肿瘤治疗和抗菌治疗方面受到了研究人员的广泛关注。此外,由于其灵活的分子结构以及多样的合成体系和方法,在医学应用中有可能根据患者的个体生理环境设计和合成材料,使生物成像更加准确,并大大提高肿瘤和细菌杀灭率。因此它们在医学领域具有巨大的发展潜力。在介绍RTP材料发出磷光并产生活性氧的机制的基础上,本综述从生物成像、肿瘤治疗和抗菌治疗三个方面总结了RTP材料的医学应用,为其在口腔医学领域的应用提供依据。