Levenberg Alex, Vinshtok Yuri, Gershonowitz Amikam
Aesthet Surg J Open Forum. 2024 Sep 10;6:ojae075. doi: 10.1093/asjof/ojae075. eCollection 2024.
Glycolic acid (GA) is an α-hydroxy peeling agent that causes controlled removal of the epidermis, with or without the dermis. Studies have shown the ability of GA to stimulate fibroblast proliferation, induce collagen synthesis, and decrease collagen degradation. The VoluDerm radiofrequency microneedling (RFMN; Pollogen, Tel Aviv, Israel) utilizes an array of microelectrodes to penetrate the epidermis and deliver energy to the skin. The controlled fractional thermal injury promotes neocollagenesis in the correction of skin laxity and wrinkle reduction. It was theorized that GA and VoluDerm could synergistically boost collagen production in combined treatment.
Safety and efficacy of the combination treatment were investigated in patients seeking corrections of the age-related skin deteriorations.
Seven female patients (aged 42-70 years, Fitzpatrick II-IV) with photo- and chrono-damaged skin received 5 treatments of VoluDerm followed by the GA peel at increasing 30% to 70% concentrations.
Clinical photography taken 6 months after the treatment demonstrated improvement in elasticity, wrinkling, roughness, pigmentation, erythema, and pore size across the entire treated group. Efficacy quantified by the physician and patients per 1 to 5 Global Aesthetic Improvement Scale was average 4.3 and 4.5, respectively. The treatments were tolerated well without preprocedural anesthesia. Skin phenomena observed after GA application were suggestive of the acid passing to deeper layers.
A novel combination of VoluDerm RFMN and GA at increased concentrations provided safe and effective synergy in the treatment of aging facial skin. Visible results demonstrated skin tightening, reduction of rhytidids, and improvement of the skin texture which may be a result of the combination.
乙醇酸（GA）是一种α-羟基脱皮剂，可导致表皮可控性去除，可累及真皮或不累及真皮。研究表明，GA具有刺激成纤维细胞增殖、诱导胶原蛋白合成以及减少胶原蛋白降解的能力。VoluDerm射频微针（RFMN；Pollogen公司，以色列特拉维夫）利用一系列微电极穿透表皮并向皮肤传递能量。可控的部分热损伤可促进新胶原蛋白生成，用于改善皮肤松弛和减少皱纹。理论上认为，GA和VoluDerm在联合治疗中可协同促进胶原蛋白生成。
在寻求改善与年龄相关皮肤老化问题的患者中，研究联合治疗的安全性和有效性。
7名患有光老化和自然老化皮肤的女性患者（年龄42 - 70岁，Fitzpatrick皮肤分型为II - IV型）接受了5次VoluDerm治疗，随后使用浓度递增30%至70%的GA进行脱皮治疗。
治疗6个月后拍摄的临床照片显示，整个治疗组在弹性、皱纹、粗糙度、色素沉着、红斑和毛孔大小方面均有改善。医生和患者根据1至5分的全球美学改善量表进行量化评估，平均疗效分别为4.3分和4.5分。治疗耐受性良好，无需术前麻醉。GA应用后观察到的皮肤现象提示酸已渗透至更深层。
VoluDerm RFMN与浓度递增的GA的新型联合治疗在面部老化皮肤治疗中提供了安全有效的协同作用。可见的效果显示出皮肤紧致、皱纹减少以及皮肤质地改善，这可能是联合治疗的结果。
