Kubota T, Hirano A, Sato K, Yamamoto S
Cancer. 1985 Feb 15;55(4):745-50. doi: 10.1002/1097-0142(19850215)55:4<745::aid-cncr2820550411>3.0.co;2-l.
An astroblastoma in the cerebrum was investigated with the electron microscope. A distinctive feature of the tumor was the radial arrangement of astrocytic cells around the blood vessels. The blood vessels in the tumor commonly exhibited fenestrated endothelial cells. The endothelium was generally surrounded by lamellated basal laminae that were compactly invested in the neoplastic cells. The most remarkable feature of the tumor cells was the frequent presence of coated vesicles. The cytoplasm of some tumor cells was filled by delicate glial fibrils and microtubules, whereas that of others contained a moderate amount of rough-surfaced endoplasmic reticulum, free ribosomes, and mitochondria, but only scanty glial fibrils and microtubules. The former usually possessed long, thin cell processes, whereas the latter had poor development of cell processes and commonly showed multiple or giant nuclei containing several nuclear bodies and prominent nucleoli. In summary, this ultrastructural study of astroblastoma revealed the coexistence of varied maturity astrocytic cells and their compact arrangement around fenestrated blood vessels.
对大脑中的成星形细胞瘤进行了电子显微镜检查。该肿瘤的一个显著特征是星形细胞围绕血管呈放射状排列。肿瘤中的血管通常可见有窗孔的内皮细胞。内皮细胞通常被层状基底膜包围，基底膜紧密包裹肿瘤细胞。肿瘤细胞最显著的特征是频繁出现被膜小泡。一些肿瘤细胞的细胞质充满纤细的胶质原纤维和微管，而另一些细胞的细胞质含有适量的粗面内质网、游离核糖体和线粒体，但胶质原纤维和微管很少。前者通常具有长而细的细胞突起，而后者细胞突起发育不良，通常显示有多个或巨大的细胞核，包含几个核体和明显的核仁。总之，这项成星形细胞瘤的超微结构研究揭示了不同成熟度的星形细胞共存以及它们在有窗孔血管周围的紧密排列。
