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儿童后颅窝成星形细胞瘤:一例病例报告及文献复习

Posterior fossa astroblastoma in a child: a case report and a review of the literature.

作者信息

Yapıcıer Özlem, Demir Mustafa Kemal, Özdamarlar Umut, Kılıç Deniz, Akakın Akın, Kılıç Türker

机构信息

Department of Pathology, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, Istanbul, Turkey.

Department of Radiology,, Bahçeşehir University School of Medicine, Göztepe Medical Park Training and Education Hospital, 11. kisim, Yasemin Apt, D blok. Daire 35 Ataköy, 34158, Istanbul, Turkey.

出版信息

Childs Nerv Syst. 2019 Jul;35(7):1251-1255. doi: 10.1007/s00381-019-04113-3. Epub 2019 Mar 12.

DOI:10.1007/s00381-019-04113-3
PMID:30859299
Abstract

A 4-year-old girl presented to the hospital with a progressive headache, difficulty walking, and persistent daily vomiting for 3 weeks. Papilledema was observed on fundoscopic examination. A large left cerebellovermian tumor with "bubbly" appearance was discovered. Total removal of the tumor mass was performed, and a diagnosis of low-grade astroblastoma was made. Adjuvant radiotherapy was performed due to the risk of recurrence. The patient is disease-free and has been kept on close follow-up for 6 months. The occurrence of posterior fossa astroblastoma has been rarely reported in the literature. Thus, when a "bubby" appearance enhancing cystic solid tumor is located on the cerebellar hemisphere in a child, an astroblastoma should also be included in the differential diagnosis.

摘要

一名4岁女孩因进行性头痛、行走困难及持续3周的每日持续性呕吐入院。眼底检查发现视乳头水肿。发现一个外观呈“泡沫状”的巨大左小脑蚓部肿瘤。行肿瘤肿块全切,诊断为低级别成星形细胞瘤。因有复发风险,进行了辅助放疗。患者无疾病复发,已密切随访6个月。后颅窝成星形细胞瘤的发生在文献中鲜有报道。因此,当儿童小脑半球出现一个呈“泡沫状”外观的强化囊实性肿瘤时,鉴别诊断中也应考虑成星形细胞瘤。

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引用本文的文献

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Posterior fossa astroblastoma: a case report of an extremely rare tumor with challenging diagnosis in a child and a review of literature.后颅窝成星形细胞瘤:1例儿童罕见肿瘤的病例报告及文献复习,该肿瘤诊断颇具挑战性
Childs Nerv Syst. 2025 Feb 14;41(1):112. doi: 10.1007/s00381-025-06768-7.

本文引用的文献

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Brainstem astroblastoma with MN1 translocation.伴有MN1易位的脑干成星形细胞瘤
Neuropathology. 2018 Dec;38(6):631-637. doi: 10.1111/neup.12514. Epub 2018 Sep 20.
2
Patterns of care and treatment outcomes of patients with astroblastoma: a National Cancer Database analysis.成星形细胞瘤患者的护理模式与治疗结果:一项国家癌症数据库分析
CNS Oncol. 2018 Apr;7(2):CNS13. doi: 10.2217/cns-2017-0038. Epub 2018 Apr 30.
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Astroblastoma - a rare and challenging tumor: a case report and review of the literature.成星形细胞瘤——一种罕见且具有挑战性的肿瘤:一例病例报告及文献综述
J Med Case Rep. 2018 Apr 21;12(1):102. doi: 10.1186/s13256-018-1623-1.
4
Patterns of care and survival outcomes in patients with astroblastoma: an individual patient data analysis of 152 cases.成星形细胞瘤患者的治疗模式与生存结局:152例患者的个体患者数据分析
Childs Nerv Syst. 2017 Aug;33(8):1295-1302. doi: 10.1007/s00381-017-3410-5. Epub 2017 May 5.
5
Morphological and molecular features of astroblastoma, including BRAFV600E mutations, suggest an ontological relationship to other cortical-based gliomas of children and young adults.成星形细胞瘤的形态学和分子特征,包括BRAFV600E突变,提示其与儿童和年轻成人的其他基于皮质的胶质瘤存在本体论关系。
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Neuroradiologic characteristics of astroblastoma and systematic review of the literature: 2 new cases and 125 cases reported in 59 publications.成星形细胞瘤的神经放射学特征及文献系统综述:2例新病例及59篇出版物中报道的125例病例
Pediatr Radiol. 2016 Aug;46(9):1301-8. doi: 10.1007/s00247-016-3607-x. Epub 2016 Apr 5.
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Surg Neurol Int. 2014 Jul 24;5:111. doi: 10.4103/2152-7806.137532. eCollection 2014.
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