Li Yan-Ruide, Zhou Kuangyi, Zhu Yichen, Halladay Tyler, Yang Lili
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Department of Microbiology, Immunology & Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA; Department of Bioengineering, University of California, Los Angeles, Los Angeles, CA 90095, USA; Molecular Biology Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA 90095, USA; Jonsson Comprehensive Cancer Center, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA 90095, USA; Parker Institute for Cancer Immunotherapy, University of California, Los Angeles, Los Angeles, CA 90095, USA.
Cancer Cell. 2025 Mar 10;43(3):317-322. doi: 10.1016/j.ccell.2024.11.010. Epub 2024 Dec 12.
Unconventional T cells, including invariant natural killer T (iNKT) cells, gamma delta (γδ) T cells, and mucosal-associated invariant T (MAIT) cells, play important roles in both innate and adaptive immunity. These cells respond to tumors rapidly and influence the tumor microenvironment (TME). Recent advances in understanding their biology, as well as the development of novel therapeutic approaches, have underscored their potential in cancer immunotherapy. This commentary will assess these advances and translational possibilities in the field.
非常规T细胞，包括不变自然杀伤T（iNKT）细胞、γδ T细胞和黏膜相关恒定T（MAIT）细胞，在固有免疫和适应性免疫中均发挥重要作用。这些细胞对肿瘤反应迅速，并影响肿瘤微环境（TME）。在理解它们生物学特性方面的最新进展以及新型治疗方法的开发，都凸显了它们在癌症免疫治疗中的潜力。本述评将评估该领域的这些进展及转化可能性。
