Sesquiterpene enantiomers from Alismatis Rhizoma.
作者信息
Liu Shan-Shan, Li Yun, An Yun-He, Zhu Jing-Jing, Zhang Mei, Wang Wei, Yan Li-Hua, Wang Zhi-Min
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, 100700, PR China; Institute of Analysis and Testing, Beijing Academy of Science and Technology (Beijing Center for Physical &Chemical Analysis), No.27, North Xisanhuan Road, Beijing, 100089, PR China.
School of Pharmaceutical Sciences, Shandong University of Traditional Chinese Medicine, Jinan, 250355, PR China.
出版信息
Phytochemistry. 2025 Apr;232:114359. doi: 10.1016/j.phytochem.2024.114359. Epub 2024 Dec 12.
A pair of dinor-sesquiterpene enantiomers (1a/1b), eight pairs of guaiane-type sesquiterpenes enantiomers (2a/2b, 3a/3b, 4a/4b, 5a/5b, 6a/6b, 7a/7b, 8a/8b, 9a/9b) and two guaiane-type sesquiterpenes (10, 11), including eleven undescribed ones (1a, 1b, 2a, 2b, 3a, 3b, 4a, 5b, 6a, 10, and 11), were isolated from the aqueous extract of Alismatis Rhizoma. The structures were elucidated by combining 1D and 2D NMR and HRESIMS spectroscopic data. The absolute configurations were determined by experimental and calculated ECD spectra, [Mo(OAc)]-induced ECD spectral analysis, and comparison of the experimental ECD spectra with those of similar analogs. Compound 5b (NO inhibition rate, 52.63%) and 8b (36.49%) showed comparable activity to indomethacin (46.36%) against LPS-induced NO production in RAW 264.7 murine macrophages at 100 μM with obvious stereoselectivity, whereas compounds 1-10 exerted no or extremely low cytotoxicities against MCF-7 and MDA-MB-231 cells (IC ＞ 100 μM).
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