来自近似霍氏灵芝天然子实体的高度修饰羊毛甾烷三萜类化合物。
Highly modified lanostane triterpenoids from natural fruiting bodies of Ganoderma cf. hochiminhense.
作者信息
Palasarn Somporn, Choowong Wilunda, Wiriyathanawudhiwong Natthawut, Choeyklin Rattaket, Isaka Masahiko
机构信息
National Center for Genetic Engineering and Biotechnology (BIOTEC), National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani 12120, Thailand.
National Biobank of Thailand, National Science and Technology Development Agency (NSTDA), 111 Thailand Science Park, Phahonyothin Road, Klong Luang, Pathumthani 12120, Thailand.
出版信息
Fitoterapia. 2025 Jan;180:106336. doi: 10.1016/j.fitote.2024.106336. Epub 2024 Dec 12.
Eight previously undescribed highly modified lanostane triterpenoids, ganoboninketals G-K (1-5), ganoboninone I (6), ganoderlactone G (7), and (24E)-3,11-dioxolanosta-8,24-dien-26-oic acid (8), were isolated from natural fruiting bodies of Ganoderma cf. hochiminhense. The structures were elucidated on the basis of NMR spectroscopic and mass spectrometry data. Ganoboninketals G (1), H (2), and J (4) exhibited antimalarial activity against Plasmodium falciparum K1 (multidrug-resistant strain) with IC values of 17, 16, and 5.1 μM, respectively.
从近似霍氏灵芝的天然子实体中分离出8个此前未被描述的高度修饰的羊毛甾烷三萜类化合物，即灵芝bonin酮G - K（1 - 5）、灵芝bonin酮I（6）、灵芝内酯G（7）和（24E）- 3,11 - 二氧杂羊毛甾 - 8,24 - 二烯 - 26 - 酸（8）。根据核磁共振光谱和质谱数据阐明了其结构。灵芝bonin酮G（1）、H（2）和J（4）对恶性疟原虫K1（多药耐药株）表现出抗疟活性，IC值分别为17、16和5.1 μM。
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