来自斯里兰卡担子菌平盖灵芝的羊毛甾烷三萜类化合物。

Lanostane triterpenoids from the Sri Lankan basidiomycete Ganoderma applanatum.

作者信息

de Silva E Dilip, van der Sar Sonia A, Santha R G Lalith, Wijesundera Ravi L C, Cole Anthony L J, Blunt John W, Munro Murray H G

机构信息

Department of Chemistry, University of Colombo, P.O. Box 1490, Colombo 3, Sri Lanka.

出版信息

J Nat Prod. 2006 Aug;69(8):1245-8. doi: 10.1021/np0602214.

DOI:10.1021/np0602214

PMID:16933889

Abstract

Two new lanostane-type triterpenoids, 3alpha,16alpha-dihydroxylanosta-7,9(11),24-trien-21-oic acid (1) and 3alpha,16alpha,26-trihydroxylanosta-7,9(11),24-trien-21-oic acid (2), along with three known lanostanoids, 16alpha-hydroxy-3-oxolanosta-7,9(11),24-trien-21-oic acid (3), 3alpha-carboxyacetoxy-24-methylen-23-oxolanost-8-en-26-oic acid (4), and 3alpha-carboxyacetoxy-24-methyl-23-oxolanost-8-en-26-oic acid (5), have been isolated from the EtOAc extract of the fruiting body of Ganoderma applanatum. The structures of 1, 2, and 3 were determined directly by the interpretation of spectroscopic data, while the structures of 4 and 5 were assigned by comparison of spectroscopic data against literature values.

摘要

从平盖灵芝子实体的乙酸乙酯提取物中分离得到了两种新的羊毛甾烷型三萜化合物，3α,16α-二羟基羊毛甾-7,9(11),24-三烯-21-酸（1）和3α,16α,26-三羟基羊毛甾-7,9(11),24-三烯-21-酸（2），以及三种已知的羊毛甾烷类化合物，16α-羟基-3-氧代羊毛甾-7,9(11),24-三烯-21-酸（3）、3α-羧基乙酰氧基-24-亚甲基-23-氧代羊毛甾-8-烯-26-酸（4）和3α-羧基乙酰氧基-24-甲基-23-氧代羊毛甾-8-烯-26-酸（5）。化合物1、2和3的结构通过光谱数据解析直接确定，而化合物4和5的结构则通过将光谱数据与文献值进行比较来确定。