Rubio Alejandro, Garzón Andrés, Moreno-Rodríguez Antonio, Pérez-Pulido Antonio J
Andalusian Center for Developmental Biology (CABD, UPO-CSIC-JA), Faculty of Experimental Sciences (Genetics Area), University Pablo de Olavide, 41013 Seville, Spain.
Andalusian Center for Developmental Biology (CABD, UPO-CSIC-JA), Faculty of Experimental Sciences (Genetics Area), University Pablo de Olavide, 41013 Seville, Spain.
Cell Rep. 2024 Dec 24;43(12):115085. doi: 10.1016/j.celrep.2024.115085. Epub 2024 Dec 13.
CRISPR-Cas systems are adaptive immunity systems of bacteria and archaea that prevent infection by viruses and other external mobile genetic elements. It is currently known that these defense systems can be co-opted by the same viruses. We have found one of these viruses in the opportunistic pathogen Acinetobacter baumannii, and the same system has been also found in an integration hotspot of the bacterial genome that harbors other multiple defense systems. The CRISPR-Cas system appears to especially target another virus that could compete with the system itself for the same integration site. This virus is prevalent in strains of the species belonging to the so-called Global Clone 2, which causes the most frequent outbreaks worldwide. Knowledge of this viral warfare involving antiviral systems could be useful in the fight against infections caused by bacteria, and it would also shed light on how CRISPR-Cas systems expand in bacteria.
CRISPR-Cas系统是细菌和古生菌的适应性免疫系统，可防止病毒和其他外部移动遗传元件的感染。目前已知这些防御系统会被相同的病毒利用。我们在机会性病原体鲍曼不动杆菌中发现了其中一种病毒，并且在含有其他多种防御系统的细菌基因组整合热点区域也发现了相同的系统。CRISPR-Cas系统似乎特别针对另一种病毒，该病毒可能会与系统本身争夺相同的整合位点。这种病毒在属于所谓全球克隆2的物种菌株中普遍存在，该物种在全球范围内引发最频繁的疫情。了解这种涉及抗病毒系统的病毒战可能有助于对抗细菌引起的感染，也将阐明CRISPR-Cas系统在细菌中是如何扩展的。
