Kumar Suraj, Malviya Rishabha, Sridhar Sathvik Belagodu, Wadhwa Tarun, Shareef Javedh, Meenakshi Dhanalekshmi Unnikrishnan
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Plot No 17 A, Yamuna Expressway, Greater Noida, U.P., India; Pragya College of Pharmaceutical Sciences, Shanti Nagar, Gaya, Bihar, India.
Department of Pharmacy, School of Medical and Allied Sciences, Galgotias University, Plot No 17 A, Yamuna Expressway, Greater Noida, U.P., India.
Ann Pharm Fr. 2025 May;83(3):407-427. doi: 10.1016/j.pharma.2024.12.004. Epub 2024 Dec 13.
Implantable drug delivery systems offer numerous benefits, including effective drug administration at lower concentrations, fewer side effects, and improved patient compliance. Various polymers are used for fabricating implants, with biopolymers, particularly polysaccharides, being notable for their ability to modulate drug delivery characteristics. The review aims to describe the strategies employed in the development of polysaccharide-based implants and provide a comprehensive understanding of various polysaccharides such as starch, cellulose, alginate, chitosan, pullulan, carrageenan, dextran, hyaluronic acid, agar, pectin, and gellan gum in the fabrication of implant for targeted therapy. The review explores the biomedical applications of polysaccharide-based implantable devices, highlighting recent advancements in the development of these systems. Detailed discussions cover implants used in the oral cavity, nasal cavity, bone, ocular applications, and antiviral therapy. Additionally, regulatory considerations concerning implantable drug delivery are emphasized. The findings of the study show that polysaccharides can be used for the development of implants for drug delivery applications.
可植入药物递送系统具有诸多优点，包括以较低浓度有效给药、副作用更少以及患者依从性提高。各种聚合物被用于制造植入物，生物聚合物，特别是多糖，因其调节药物递送特性的能力而备受关注。本综述旨在描述基于多糖的植入物开发中所采用的策略，并全面了解各种多糖，如淀粉、纤维素、藻酸盐、壳聚糖、普鲁兰多糖、卡拉胶、葡聚糖、透明质酸、琼脂、果胶和结冷胶在制造用于靶向治疗的植入物中的应用。本综述探讨了基于多糖的可植入装置的生物医学应用，突出了这些系统开发中的最新进展。详细讨论涵盖了用于口腔、鼻腔、骨骼、眼部应用和抗病毒治疗的植入物。此外，还强调了与可植入药物递送相关的监管考虑因素。研究结果表明，多糖可用于开发用于药物递送应用的植入物。
