Mulry J T
Drug Intell Clin Pharm. 1985 Jan;19(1):32-3. doi: 10.1177/106002808501900108.
A 29-year-old man used codeine approximately 1000 mg/d for seven years prior to detoxification. He developed dose-related clonidine side effects of dizziness, sedation, and dysphoria during standard clonidine detoxification; however, opiate withdrawal symptoms persisted. Conversion to guanabenz, a clonidine-like alpha 2 agonist, promptly relieved the opiate withdrawal symptoms without side effect recurrence. Guanabenz shows promise as an opiate withdrawal agent.
一名29岁男性在戒毒前七年每天使用约1000毫克可待因。在标准可乐定戒毒过程中，他出现了与剂量相关的可乐定副作用，如头晕、镇静和烦躁不安；然而，阿片类药物戒断症状持续存在。改用胍法辛，一种类似可乐定的α2激动剂，迅速缓解了阿片类药物戒断症状，且未再次出现副作用。胍法辛有望成为一种阿片类药物戒断剂。
