Sia Tonnii, Wong Tze-Cheng, Ong Yee-Chiing
School of Public Health, Imperial College London, London SW7 2AZ, UK.
Infectious Diseases Unit, Department of Medicine, Sarawak General Hospital, 93586 Kuching, Sarawak, Malaysia.
Trans R Soc Trop Med Hyg. 2025 May 1;119(5):534-537. doi: 10.1093/trstmh/trae134.
Dengue is a vector-borne infection, which contributes to significant morbidity and mortality in endemic areas. It manifests rapidly within 2 wk from febrile, critical to recovery phase. The point-of-care test (POCT) comprises the non-structural protein 1 (NS1) antigen, IgM and IgG, which aids rapid diagnosis, leading to timely treatment. Despite the high specificity of various POCTs, a few false-positive NS1 cases have been reported. We report the first case of false-positive NS1 antigen in pregnancy. A 24-y-old female in her second trimester of pregnancy presented with fever and chills for 9 d and a non-productive cough for 3 d. The dengue POCT showed NS1 antigen positive, IgM and IgG negative. Her symptoms were resolved with treatment of urinary tract infection with cefuroxime. Urine culture subsequently yielded Escherichia coli. Her recovery and delivery were uneventful. Her NS1 antigen was persistently positive for 18 d. The confirmatory real time-PCR for dengue and pan-Flaviviruses was negative.
登革热是一种媒介传播感染病，在流行地区会导致严重的发病和死亡。它在发热期至恢复期的2周内迅速显现。即时检验（POCT）包括非结构蛋白1（NS1）抗原、IgM和IgG，有助于快速诊断，从而实现及时治疗。尽管各种POCT具有高特异性，但仍有一些NS1假阳性病例的报道。我们报告了首例妊娠期间NS1抗原假阳性病例。一名24岁处于妊娠中期的女性，发热、寒战9天，干咳3天。登革热POCT显示NS1抗原阳性，IgM和IgG阴性。使用头孢呋辛治疗尿路感染后，她的症状得到缓解。随后尿液培养发现大肠杆菌。她的康复和分娩过程顺利。她的NS1抗原持续阳性达18天。登革热和泛黄病毒的实时荧光定量PCR确诊结果为阴性。
