• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

神经元“集合”记录与细胞集群的探索:个人历程

Neuronal 'Ensemble' Recording and the Search for the Cell Assembly: A Personal History.

作者信息

McNaughton Bruce L

机构信息

Department of Neurobiology and Behavior, University of California Irvine, Irvine, USA.

Department of Neuroscience, The University of Lethbridge, Irvine, USA.

出版信息

Hippocampus. 2025 Jan;35(1):e23669. doi: 10.1002/hipo.23669.

DOI:10.1002/hipo.23669
PMID:39676610
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11647560/
Abstract

This contribution is part of the special issue on the Hippocampus focused on personal histories of advances in knowledge on the hippocampus and related structures. An account is offered of the author's role in the development of neural ensemble recording: stereo recording (stereotrodes, tetrodes) and the use of this approach to search for evidence of Hebb's "cell assemblies" and "phase sequences", the holy grail of the neuroscience of learning and memory.

摘要

本论文是关于海马体特刊的一部分,该特刊聚焦于海马体及相关结构知识进展的个人历程。本文讲述了作者在神经集群记录技术发展中的作用:立体记录(立体电极、四极管),以及使用这种方法寻找赫布“细胞集合体”和“相位序列”证据的过程,这些都是学习与记忆神经科学的圣杯。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/3383a1f39963/HIPO-35-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/34a8932e13a8/HIPO-35-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/bcbb6b8f2d58/HIPO-35-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/ef4650dd5ad3/HIPO-35-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/41c8e8749e5f/HIPO-35-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/3383a1f39963/HIPO-35-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/34a8932e13a8/HIPO-35-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/bcbb6b8f2d58/HIPO-35-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/ef4650dd5ad3/HIPO-35-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/41c8e8749e5f/HIPO-35-0-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2da0/11647560/3383a1f39963/HIPO-35-0-g004.jpg

相似文献

1
Neuronal 'Ensemble' Recording and the Search for the Cell Assembly: A Personal History.神经元“集合”记录与细胞集群的探索:个人历程
Hippocampus. 2025 Jan;35(1):e23669. doi: 10.1002/hipo.23669.
2
Cell assemblies in the cerebral cortex.大脑皮层中的细胞集合体。
Biol Cybern. 2014 Oct;108(5):559-72. doi: 10.1007/s00422-014-0596-4. Epub 2014 Apr 2.
3
Robert U. Muller-in memory.罗伯特·U·穆勒——纪念
Hippocampus. 2014 Jun;24(6):611-4. doi: 10.1002/hipo.22269. Epub 2014 Mar 18.
4
Donald O. Hebb's synapse and learning rule: a history and commentary.唐纳德·O·赫布的突触与学习规则:一段历史及评论
Neurosci Biobehav Rev. 2005 Jan;28(8):851-74. doi: 10.1016/j.neubiorev.2004.09.009.
5
An investigation of Hebbian phase sequences as assembly graphs.作为装配图的赫布相位序列研究。
Front Neural Circuits. 2014 Apr 8;8:34. doi: 10.3389/fncir.2014.00034. eCollection 2014.
6
The legacy of Donald O. Hebb: more than the Hebb synapse.唐纳德·O·赫布的遗产:不止于赫布突触。
Nat Rev Neurosci. 2003 Dec;4(12):1013-9. doi: 10.1038/nrn1257.
7
Donald O. Hebb and the Organization of Behavior: 17 years in the writing.唐纳德·O·赫布与《行为的组织》:历时17年撰写而成。
Mol Brain. 2020 Apr 6;13(1):55. doi: 10.1186/s13041-020-00567-8.
8
Hebb's concept of synaptic plasticity and neuronal cell assemblies.赫布关于突触可塑性和神经元细胞集合的概念。
Behav Brain Res. 1996 Jun;78(1):3-7. doi: 10.1016/0166-4328(95)00221-9.
9
Obituary: A career that transformed neuroscience.讣告:一段改变神经科学的职业生涯。
Brain Res Bull. 2011 Nov 25;86(5-6):285-6. doi: 10.1016/j.brainresbull.2011.09.004.
10
The biology of memory: a forty-year perspective.记忆生物学:四十年的视角
J Neurosci. 2009 Oct 14;29(41):12748-56. doi: 10.1523/JNEUROSCI.3958-09.2009.

引用本文的文献

1
Visual Exploration and the Primate Hippocampal Formation.视觉探索与灵长类动物海马结构
Hippocampus. 2025 Jan;35(1):e23673. doi: 10.1002/hipo.23673.
2
Unweaving the Cognitive Map: A Personal History.拆解认知地图:一段个人历程。
Hippocampus. 2025 Jan;35(1):e23674. doi: 10.1002/hipo.23674.
3
Hippocampal Discoveries: Spatial View Cells, Connectivity, and Computations for Memory and Navigation, in Primates Including Humans.海马体的新发现:空间视图细胞、连接性以及包括人类在内的灵长类动物记忆与导航的计算

本文引用的文献

1
Mental Time Travel: A Retrospective.心理时光旅行:回顾
Hippocampus. 2025 Jan;35(1):e23661. doi: 10.1002/hipo.23661.
2
Current Practice in Using Voltage Imaging to Record Fast Neuronal Activity: Successful Examples from Invertebrate to Mammalian Studies.当前使用电压成像记录快速神经元活动的实践:无脊椎动物到哺乳动物研究中的成功案例。
Biosensors (Basel). 2023 Jun 13;13(6):648. doi: 10.3390/bios13060648.
3
Fluorescence imaging of large-scale neural ensemble dynamics.大规模神经组合动力学的荧光成像。
Hippocampus. 2025 Jan;35(1):e23666. doi: 10.1002/hipo.23666.
4
Mental Time Travel: A Retrospective.心理时光旅行:回顾
Hippocampus. 2025 Jan;35(1):e23661. doi: 10.1002/hipo.23661.
Cell. 2022 Jan 6;185(1):9-41. doi: 10.1016/j.cell.2021.12.007.
4
Identification of Pattern Completion Neurons in Neuronal Ensembles Using Probabilistic Graphical Models.利用概率图模型识别神经元集合中的模式完成神经元。
J Neurosci. 2021 Oct 13;41(41):8577-8588. doi: 10.1523/JNEUROSCI.0051-21.2021. Epub 2021 Aug 19.
5
Two-Photon Voltage Imaging of Spontaneous Activity from Multiple Neurons Reveals Network Activity in Brain Tissue.多个神经元自发活动的双光子电压成像揭示脑组织中的网络活动。
iScience. 2020 Aug 21;23(8):101363. doi: 10.1016/j.isci.2020.101363. Epub 2020 Jul 12.
6
Controlling Visually Guided Behavior by Holographic Recalling of Cortical Ensembles.通过皮层集合的全息回忆来控制视觉引导行为。
Cell. 2019 Jul 11;178(2):447-457.e5. doi: 10.1016/j.cell.2019.05.045. Epub 2019 Jun 27.
7
Multiple Approaches to the Investigation of Cell Assembly in Memory Research-Present and Future.记忆研究中细胞集合体研究的多种方法——现状与未来
Front Syst Neurosci. 2018 May 25;12:21. doi: 10.3389/fnsys.2018.00021. eCollection 2018.
8
A robotic multidimensional directed evolution approach applied to fluorescent voltage reporters.一种应用于荧光电压报告基因的机器人多维定向进化方法。
Nat Chem Biol. 2018 Apr;14(4):352-360. doi: 10.1038/s41589-018-0004-9. Epub 2018 Feb 26.
9
Integration of silicon-based neural probes and micro-drive arrays for chronic recording of large populations of neurons in behaving animals.用于在行为动物中对大量神经元进行长期记录的硅基神经探针与微驱动阵列的集成。
J Neural Eng. 2016 Aug;13(4):046018. doi: 10.1088/1741-2560/13/4/046018. Epub 2016 Jun 28.
10
Spike sorting for large, dense electrode arrays.用于大型密集电极阵列的尖峰分类
Nat Neurosci. 2016 Apr;19(4):634-641. doi: 10.1038/nn.4268. Epub 2016 Mar 14.