白细胞介素-10作为代谢危险因素的新型生物标志物。
Interleukin-10 as a novel biomarker of metabolic risk factors.
作者信息
Kulshrestha Himani, Gupta Vani, Mishra Sameeksha, Mahdi Abbas Ali, Awasthi Shelly, Kumar Sandeep
机构信息
Department of Physiology, King George's Medical University, Lucknow, India.
Department of Physiology, King George's Medical University, Lucknow, India.
出版信息
Diabetes Metab Syndr. 2018 Jul;12(4):543-547. doi: 10.1016/j.dsx.2018.03.019. Epub 2018 Mar 27.
BACKGROUND
Interleukin-10 (IL-10) is an adipocytokine that is abundantly expressed in visceral fat tissue. We investigated the association of interleukin-10 with the number of metabolic risk factors.
FINDING
The study population comprised 220 children who underwent annual health checkups. Plasma Interleukin-10 levels were determined by enzyme-linked immunosorbent assay. We divided the subjects into 4 groups according to Interleukin-10 levels. A reduction of plasma interleukin-10 levels significantly correlated with an increase in the mean number of metabolic risk factors such as increased waist circumference, BMI, dyslipidaemia, high blood pressure and glucose intolerance.
CONCLUSIONS
Circulating Interleukin-10 levels negatively correlated with the multiplicity of metabolic risk factors, suggesting that IL-10 acts as a biomarker of metabolic disorders.
背景
白细胞介素-10（IL-10）是一种在内脏脂肪组织中大量表达的脂肪细胞因子。我们研究了白细胞介素-10与代谢风险因素数量之间的关联。
研究结果
研究人群包括220名接受年度健康检查的儿童。通过酶联免疫吸附测定法测定血浆白细胞介素-10水平。我们根据白细胞介素-10水平将受试者分为4组。血浆白细胞介素-10水平的降低与代谢风险因素平均数量的增加显著相关，如腰围增加、体重指数（BMI）、血脂异常、高血压和葡萄糖耐量异常。
结论
循环白细胞介素-10水平与代谢风险因素的多样性呈负相关，提示IL-10可作为代谢紊乱的生物标志物。
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