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完整鱼皮移植为糖尿病足溃疡治疗带来新希望：一例报告

Intact fish skin graft a new hope for the treatment of diabetic foot ulcers: A case report.

作者信息

Jugnet Anne Christine, Benard Tatiana, Lequint Corinne, Bobony Elise, Pieheiro Anna-Rosiana, Winther Thomas, Penfornis Alfred, Dardari Dured

机构信息

Department of Diabetology, Centre Hospitalier Sud Francilien, Corbeil Essonne 91100, France.

出版信息

World J Diabetes. 2024 Dec 15;15(12):2353-2359. doi: 10.4239/wjd.v15.i12.2353.

DOI:10.4239/wjd.v15.i12.2353
PMID:39676802
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11580594/
Abstract

BACKGROUND

Diabetic foot ulcers (DFUs) are a real public health problem which carry a high risk of amputation. The treatment of DFUs is based on general management such as the treatment of infection, arterial disease, and offloading, but recent studies have shown that the quality of the local covering can impact the healing rate.

CASE SUMMARY

We report the case of a 39-year-old man, living with diabetes since the age of 15, who developed DFU on the dorsum of his left foot, with muscle and tendon involvement. Conventional management with intensive diabetes control, surgery, treatment of infection and negative pressure therapy gave only limited results. The patient benefited from the application of an intact fish skin graft with complete epithelialisation of the ulcer after 10 weeks of treatment.

CONCLUSION

The use of intact fish skin graft appears to be a promising option for deep DFUs.

摘要

背景

糖尿病足溃疡（DFU）是一个切实存在的公共卫生问题，截肢风险很高。DFU的治疗基于一般管理措施，如感染治疗、动脉疾病治疗和减压，但最近的研究表明，局部覆盖的质量会影响愈合速度。

病例摘要

我们报告了一名39岁男性的病例，他自15岁起患有糖尿病，左脚背出现DFU，伴有肌肉和肌腱受累。强化糖尿病控制、手术、感染治疗和负压治疗等传统管理措施效果有限。经过10周的治疗，患者通过应用完整的鱼皮移植实现了溃疡完全上皮化。

结论

对于深度DFU，使用完整的鱼皮移植似乎是一个有前景的选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/f704ea34c7eb/WJD-15-2353-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/d935e7b2de59/WJD-15-2353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/a962ccca940a/WJD-15-2353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/4051ed13a22e/WJD-15-2353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/4884a09eee05/WJD-15-2353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/f704ea34c7eb/WJD-15-2353-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/d935e7b2de59/WJD-15-2353-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/a962ccca940a/WJD-15-2353-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/4051ed13a22e/WJD-15-2353-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/4884a09eee05/WJD-15-2353-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/26a2/11580594/f704ea34c7eb/WJD-15-2353-g005.jpg

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Medicina (Kaunas). 2022 Dec 1;58(12):1775. doi: 10.3390/medicina58121775.
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Predicting Amputation in Patients With Diabetic Foot Ulcers: A Systematic Review.预测糖尿病足溃疡患者的截肢情况：一项系统评价
Cureus. 2022 Jul 25;14(7):e27245. doi: 10.7759/cureus.27245. eCollection 2022 Jul.
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C-reactive protein and diabetic foot ulcer infections: A meta-analysis.
C-反应蛋白与糖尿病足溃疡感染：荟萃分析。
J Tissue Viability. 2022 Aug;31(3):537-543. doi: 10.1016/j.jtv.2022.05.001. Epub 2022 May 7.
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Curing Necrotic Angiodermatitis with an Intact Fish Skin Graft in a Patient Living with Diabetes.糖尿病患者应用完整鱼皮移植治疗坏疽性血管炎
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The diabetic foot ulcer.糖尿病足溃疡。
Aust J Gen Pract. 2020 May;49(5):250-255. doi: 10.31128/AJGP-11-19-5161.
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Practical Guidelines on the prevention and management of diabetic foot disease (IWGDF 2019 update).《糖尿病足病预防与管理实用指南（IWGDF 2019 更新版）》
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