Dorweiler B, Trinh T T, Dünschede F, Vahl C F, Debus E S, Storck M, Diener H
1Vascular Surgical Unit, Department of Cardiac, Thoracic, and Vascular Surgery, Mainz University Hospital, Langenbeckstraße 1, 55131 Mainz, Germany.
2Department and Outpatient Clinic for Vascular Medicine, University Heart Center Hamburg, Hamburg-Eppendorf University Hospital, Hamburg, Germany.
Gefasschirurgie. 2018;23(Suppl 2):46-55. doi: 10.1007/s00772-018-0428-2. Epub 2018 Aug 1.
The Kerecis™ Omega3 Wound matrix is a decellularized skin matrix derived from fish skin and represents an innovative concept to achieve wound healing. The aim of this study was to report the cumulative experience of three centers for vascular surgery regarding use of the Omega3 Wound matrix in selected patients with complicated wounds.
In this study 23 patients with 25 vascular and/or diabetes mellitus-associated complicated wounds and partially exposed bony segments were treated with the Omega3 Wound matrix in three vascular centers. In several patients, conventional wound treatment with vacuum therapy had previously been carried out sometimes over several weeks without durable success. Following initial debridement in the operating room, the matrix was applied and covered with a silicone mesh. In the further course, wound treatment was conducted on an outpatient setting if possible.
In total 25 wounds were treated with localization at the level of the thigh ( = 2), the distal calf ( = 7), the forefoot ( = 14) and the hand ( = 2). The time to heal varied between 9 and 41 weeks and between 3 and 26 wound matrices were applied per wound. Interestingly, a reduction of analgesics intake was noted when the treatment with the Omega3 Wound matrix was initiated.
The novel Omega3 Wound matrix in this study represented an effective treatment option in 25 complicated wounds. Further studies are necessary to evaluate the impact of the wound matrix on stimulation of granulation tissue and re-epithelialization as well as the potential antinociceptive and analgetic effects.
Kerecis™欧米伽3伤口基质是一种源自鱼皮的脱细胞皮肤基质，代表了一种实现伤口愈合的创新理念。本研究的目的是报告三个血管外科中心在选定的复杂伤口患者中使用欧米伽3伤口基质的累积经验。
在本研究中，三个血管中心对23例患有25处血管和/或糖尿病相关复杂伤口且部分骨质外露的患者使用了欧米伽3伤口基质进行治疗。在一些患者中，之前有时会进行数周的常规负压伤口治疗，但未取得持久成功。在手术室进行初步清创后，应用该基质并覆盖硅胶网。在后续过程中，尽可能在门诊进行伤口治疗。
共治疗了25处伤口，部位分别为大腿（2处）、小腿远端（7处）、前足（14处）和手部（2处）。愈合时间在9至41周之间，每个伤口应用3至26片伤口基质。有趣的是，开始使用欧米伽3伤口基质治疗后，患者的镇痛药摄入量有所减少。
本研究中的新型欧米伽3伤口基质是治疗25例复杂伤口的有效选择。需要进一步研究以评估伤口基质对肉芽组织刺激和再上皮化的影响以及潜在的抗伤害感受和镇痛作用。
