Sazmand Alireza, Khordadmehr Monireh, Önder Zuhal, Oryan Ahmad, Jigari-Asl Farinaz, Katiraee Farzad, Namavari Mehdi, Bahiraei Zahra, Hemphill Andrew, Otranto Domenico
Department of Pathobiology, Faculty of Veterinary Medicine, Bu-Ali Sina University, 651765-8978, Hamedan, Iran.
Department of Pathobiology, Faculty of Veterinary Medicine, University of Tabriz, 516665-1647, Tabriz, Iran.
Curr Res Parasitol Vector Borne Dis. 2024 Nov 23;7:100232. doi: 10.1016/j.crpvbd.2024.100232. eCollection 2025.
To determine the occurrence of microsporidiosis in domestic pigeons in Iran, privately-owned pigeons presenting weight loss and diarrhea were tested through molecular and histopathological methods. Multiplex-PCR findings showed 57%, 30%, and 14% positivity for , , and mixed infection in the fecal samples, respectively. A novel genotype, named IrnEb1, falling into zoonotic group 1 of , and a novel genotype of , named Irn2E, clustering as a sister taxon to genotype 2B were identified in pigeons for the first time using Sanger sequencing and phylogenetic analyses. Histopathological examination revealed the occurrence of non-suppurative enteritis, nephritis, pneumonia, hepatitis, and encephalitis associated with focal necrosis and inflammatory cell infiltration. Data shown herein present a high prevalence of microsporidiosis in pigeons in Iran. Considering that both detected microsporidian species are zoonotic parasites, these findings suggest that the infected pigeons could pose a risk to public health.
为确定伊朗家鸽微孢子虫病的发病情况，对出现体重减轻和腹泻症状的私人饲养鸽子采用分子和组织病理学方法进行检测。多重聚合酶链反应结果显示，粪便样本中、和混合感染的阳性率分别为57%、30%和14%。首次使用桑格测序和系统发育分析在鸽子中鉴定出一种新的基因型，命名为IrnEb1，属于的人畜共患病第1组，以及一种新的基因型，命名为Irn2E，聚类为基因型2B的姐妹分类单元。组织病理学检查显示出现了非化脓性肠炎、肾炎、肺炎、肝炎和脑炎，伴有局灶性坏死和炎性细胞浸润。本文所示数据表明伊朗鸽子中微孢子虫病的患病率很高。鉴于检测到的两种微孢子虫物种均为人畜共患寄生虫，这些发现表明受感染的鸽子可能对公共卫生构成风险。
