Catania A, Cantalamessa L, Gasparini P, Mosca G, Orsatti A, Gavinelli M, Mariscotti C
Horm Metab Res. 1985 Jan;17(1):49-50. doi: 10.1055/s-2007-1013449.
Circulating thyroglobulin and antithyroglobulin antibodies were assayed in fifteen patients affected by solitary "cold" nodules of the thyroid who had undergone fine needle aspiration for cytologic diagnosis. The aim of the study was to investigate whether a minor insult to thyroid tissue such as fine needle aspiration is able to release thyroglobulin into the circulation and to induce the formation of antithyroglobulin antibodies. The results obtained are as follows: 1. Circulating thyroglobulin increased substantially after fine needle aspiration in 11 out of 15 patients. 2. Antithyroglobulin antibodies did not appear in any patient during a follow-up period of two months. 3. The magnitude of basal thyroglobulin and thyroglobulin increase after needle aspiration were unrelated to cytologic diagnosis.
对15例患有甲状腺单发“冷”结节且已接受细针穿刺进行细胞学诊断的患者检测了循环甲状腺球蛋白和抗甲状腺球蛋白抗体。本研究的目的是调查诸如细针穿刺这样对甲状腺组织的轻微损伤是否能够将甲状腺球蛋白释放到循环中，并诱导抗甲状腺球蛋白抗体的形成。获得的结果如下：1. 15例患者中有11例在细针穿刺后循环甲状腺球蛋白大幅增加。2. 在两个月的随访期内，任何患者均未出现抗甲状腺球蛋白抗体。3. 穿刺前基础甲状腺球蛋白水平及穿刺后甲状腺球蛋白增加的幅度与细胞学诊断无关。
