Şahin Muhammed Abdulkerim, Aydemir Mustafa Doğukan, Dönmez Çolakoğlu Berril, Çakmur Raif, Ünal Belgin, Gülbahar Selmin
Department of Physical Medicine and Rehabilitation, Division of Rheumatology, Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine, Istanbul, Türkiye.
Department of Physical Medicine and Rehabilitation, Dokuz Eylül University Faculty of Medicine, Izmir, Türkiye.
Turk J Phys Med Rehabil. 2024 Apr 18;70(3):379-389. doi: 10.5606/tftrd.2024.13026. eCollection 2024 Sep.
This study aims to evaluate the effect of osteoporosis education on osteoporosis knowledge level (OKL) and behavioral changes in daily life in patients with Parkinson's disease (PD).
Between May 2019 and December 2019, a total of 54 patients (34 males, 20 females; median age: 68.5 years; range, 50 to 87 years) were included in the study. We randomly assigned in a 1:1 ratio, patients with PD to receive either only the brochure or in addition to this a verbal osteoporosis education. The patients were randomized into the control (n=27) and intervention groups (n=27). Seven of the patients (two in the control group and five in the intervention group) were lost to follow-up. The patients were assessed at baseline and Week 12. The primary outcomes were Physical Activity Scale for the Elderly (PASE) score (0-400) and daily calcium intake (DCI). The secondary outcomes were revised 2011 osteoporosis knowledge test (rOKT) score (0-32), frequency of falls, smoking and alcohol use at Week 12.
The median total PASE score was 81 (range, 0 to 205) for the intervention group, compared to 61 (range, 0 to 242) for control group at Week 12. There was no statistically significant difference between the groups at Week 12, except for the medians of the frequency of falls that was significantly lower in the intervention group (p<0.05). A significant improvement from baseline was observed in the median rOKT scores (control group 16 (range, 6 to 21) to 19 (range, 11 to 25); intervention group 13 (range, 6 to 24) to 18 (range, 9 to 24); p<0.001) and DCI (control group 855 (range, 420 to 1,640) to 890 (range, 550 to 1,660); intervention group, 870 (range, 400 to 1,385) to 1,020 (range, 400 to 1,940) mg/day; p<0.01) in both groups. Also, a significant improvement in the leisure activities (PASE subgroup) was observed in the intervention group (p<0.05).
Osteoporosis education had some positive effects in patients with PD, even when only given the brochure. With additional verbal education, more benefits can be obtained.
本研究旨在评估骨质疏松症教育对帕金森病（PD）患者骨质疏松症知识水平（OKL）及日常生活行为改变的影响。
在2019年5月至2019年12月期间，共有54例患者（34例男性，20例女性；中位年龄：68.5岁；范围为50至87岁）纳入本研究。我们以1:1的比例将PD患者随机分组，一组仅接受宣传册，另一组除宣传册外还接受口头骨质疏松症教育。患者被随机分为对照组（n = 27）和干预组（n = 27）。7例患者（对照组2例，干预组5例）失访。在基线和第12周对患者进行评估。主要结局指标为老年人身体活动量表（PASE）评分（0 - 400）和每日钙摄入量（DCI）。次要结局指标为2011年修订的骨质疏松症知识测试（rOKT）评分（0 - 32）、第12周时的跌倒频率、吸烟和饮酒情况。
在第12周时，干预组的PASE总分中位数为81（范围为0至205），而对照组为61（范围为0至242）。除干预组的跌倒频率中位数显著较低（p < 0.05）外，两组在第12周时无统计学显著差异。两组的rOKT评分中位数（对照组从16（范围为6至21）提高到19（范围为11至25）；干预组从13（范围为6至24）提高到18（范围为9至24）；p < 0.001）和DCI（对照组从855（范围为420至1640）提高到890（范围为550至1660）；干预组从870（范围为400至1385）提高到1020（范围为400至1940）mg/天；p < 0.01）均较基线有显著改善。此外，干预组的休闲活动（PASE亚组）有显著改善（p < 0.05）。
骨质疏松症教育对PD患者有一些积极影响，即使仅给予宣传册。额外的口头教育可获得更多益处。
