Miadonna A, Leggieri E, Tedeschi A, Cottini M, Invernizzi F, Froldi M, Zanussi C
Int Arch Allergy Appl Immunol. 1985;76(2):120-5. doi: 10.1159/000233677.
Basophil activation, observed in patients with idiopathic mixed cryoglobulinemia, has been related to the complement anaphylatoxins C4a, C3a and C5a. In the present study the plasma levels of the complement anaphylatoxins have been evaluated in 21 patients affected with idiopathic mixed cryoglobulinemia. The plasma concentration of C3a desArg was significantly higher in the patients than in the healthy controls; conversely the plasma values of C4a desArg were significantly lower. C5a desArg was not detectable in plasma from any subject. The high plasma level of C3a desArg in our patients may suggest a role for C3a anaphylatoxin in 'in vivo' basophil activation. No correlation was found between the plasma concentrations of C3a desArg or C4a desArg, the amount of cryoprecipitate and the clinical activity of the disease.
在特发性混合性冷球蛋白血症患者中观察到的嗜碱性粒细胞活化与补体过敏毒素C4a、C3a和C5a有关。在本研究中，对21例特发性混合性冷球蛋白血症患者的补体过敏毒素血浆水平进行了评估。患者血浆中C3a desArg的浓度显著高于健康对照组；相反，C4a desArg的血浆值显著较低。在任何受试者的血浆中均未检测到C5a desArg。我们患者中较高的血浆C3a desArg水平可能提示C3a过敏毒素在“体内”嗜碱性粒细胞活化中起作用。未发现C3a desArg或C4a desArg的血浆浓度、冷沉淀物量与疾病临床活动之间存在相关性。
