Constanzo J, Pouget J-P
Nuclear Medicine Department, Institut Régional du Cancer de Montpellier (ICM), Institut de Recherche en Cancérologie de Montpellier (IRCM), INSERM U1194, Université de Montpellier, Équipe Labellisée Ligue Contre le Cancer, 208 rue des apothicaires, 34298 Montpellier, France.
J Radiat Res. 2024 Dec 16;65(Supplement_1):i6-i14. doi: 10.1093/jrr/rrae084.
Conventional radiation therapy can restore the ability of cells to undergo immunogenic cell death. Recent preclinical studies suggest that targeted radionuclide therapy, which delivers radiation to tumors at a continuous low dose rate, also stimulates the immune system and offers a promising approach for overcoming resistance to immune checkpoint inhibitors. In this context, we examined the growing body of preclinical and clinical findings showing that the immune system can be activated by the release of extracellular vesicles from irradiated cells, contributing to the antitumor immunity.
传统放射治疗可恢复细胞发生免疫原性细胞死亡的能力。最近的临床前研究表明，以持续低剂量率向肿瘤递送辐射的靶向放射性核素治疗也能刺激免疫系统，并为克服对免疫检查点抑制剂的耐药性提供了一种有前景的方法。在此背景下，我们研究了越来越多的临床前和临床研究结果，这些结果表明，受照射细胞释放的细胞外囊泡可激活免疫系统，从而促进抗肿瘤免疫。
