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镰状细胞病中的股骨头缺血性坏死。来自尼日利亚几内亚草原地区的系列病例。

Avascular necrosis of the femoral head in sickle-cell disease. A series from the Guinea Savannah of Nigeria.

作者信息

Iwegbu C G, Fleming A F

出版信息

J Bone Joint Surg Br. 1985 Jan;67(1):29-32. doi: 10.1302/0301-620X.67B1.3968138.

DOI:10.1302/0301-620X.67B1.3968138
PMID:3968138
Abstract

Of 899 patients with sickle-cell disease, aged between 6 and 28 years, who attended clinics in the Guinea Savannah of Nigeria in 1982 and 1983, 29 had symptoms of avascular necrosis of the femoral head. This group was studied in detail. Twenty-eight patients had haemoglobin-SS electrophoretic patterns and one had haemoglobin-SC. The male to female ratio was 1 to 1.6, and most of the patients were aged between 6 and 15 years at the onset of hip symptoms. These symptoms correlated with the radiographic lesions, but were not related to the age or sex of the patient. The radiographic lesions varied widely and were related to the age at onset of hip symptoms. A new radiological classification is proposed.

摘要

1982年和1983年期间,在尼日利亚几内亚草原地区诊所就诊的899例6至28岁镰状细胞病患者中,29例有股骨头缺血性坏死症状。对这组患者进行了详细研究。28例患者血红蛋白电泳呈SS型,1例呈SC型。男女比例为1比1.6,大多数患者髋关节症状出现时年龄在6至15岁之间。这些症状与影像学病变相关,但与患者的年龄和性别无关。影像学病变差异很大,且与髋关节症状出现时的年龄有关。本文提出了一种新的放射学分类方法。

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Avascular necrosis of the femoral head in sickle-cell disease. A series from the Guinea Savannah of Nigeria.镰状细胞病中的股骨头缺血性坏死。来自尼日利亚几内亚草原地区的系列病例。
J Bone Joint Surg Br. 1985 Jan;67(1):29-32. doi: 10.1302/0301-620X.67B1.3968138.
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Avascular necrosis of the hip in the sickle cell hemoglobinopathies.镰状细胞血红蛋白病中的髋关节缺血性坏死。
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The radiological features of avascular necrosis of the femoral head in homozygous sickle cell disease.纯合子镰状细胞病患者股骨头缺血性坏死的放射学特征。
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[Appearance on X-ray and computed tomography of femoral head necrosis in patients with sickle cell disease].[镰状细胞病患者股骨头坏死的X线及计算机断层扫描表现]
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Impact of Sickle Cell Disease on Affected Individuals in Nigeria: A Critical Review.镰状细胞病对尼日利亚患者的影响:一项批判性综述。
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ADAMTS-7 exhibits elevated expression in cartilage of osteonecrosis of femoral head and has a positive correlation with TNF- α and NF- κ B P65.ADAMTS-7在股骨头坏死的软骨中表达升高,且与TNF-α和NF-κB P65呈正相关。
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