Harth Sebastian, Metze Lena, Leufkens Daniel, Roller Fritz C, Brose Alexander, Zeppernick Felix, Meinhold-Heerlein Ivo, Krombach Gabriele A
Department of Diagnostic and Interventional Radiology, University Hospital Gießen, Justus Liebig University of Gießen, Klinikstr. 33, 35392, Giessen, Germany.
Department of Medicine, Institute of Medical Informatics, Justus Liebig University of Gießen, Rudolf-Buchheim-Straße 6, 35392, Giessen, Germany.
Sci Rep. 2024 Dec 16;14(1):30507. doi: 10.1038/s41598-024-82407-6.
Anogenital distance (AGD) is regarded as a potential biomarker for endometriosis, and a measurement on MRI images has been found to be promising. This study aimed to evaluate the measurement of AGD on MRI to predict the surgical diagnosis of endometriosis. We included 127 patients who received an MRI for endometriosis between October 2018 and February 2023. AGD was measured on MRI by two readers (MRI-AGD-AC: clitoris to anus; MRI-AGD-AF: posterior fourchette to anus). The feasibility and interobserver reliability of AGD measurements were evaluated. Differences in AGD between patient groups were analyzed. The intraclass correlation coefficient estimates indicated a good to excellent reliability of MRI-AGD-AC (0.92; 95% CI: 0.83-0.95) and a poor to good reliability of MRI-AGD-AF (0.68; 95% CI: 0.27-0.83). No statistically significant differences in the mean MRI-AGD-AC and MRI-AGD-AF in patients with and without surgical diagnosis of DIE (p = 0.413; p = 0.110), peritoneal endometriosis with and without DIE (p = 0.641; p = 0.323), and ovarian endometriosis (p = 0.155; p = 0.150) were found. The AUC ranged from 0.475 (95% CI: 0.365-0.584) to 0.586 (95% CI: 0.454-0.718). Thus, AGD does not constitute a valuable biomarker for patients with clinically suspected endometriosis.
肛门生殖器距离（AGD）被视为子宫内膜异位症的一种潜在生物标志物，并且已发现磁共振成像（MRI）图像测量具有前景。本研究旨在评估MRI上AGD的测量，以预测子宫内膜异位症的手术诊断。我们纳入了2018年10月至2023年2月期间接受子宫内膜异位症MRI检查的127例患者。由两名阅片者在MRI上测量AGD（MRI-AGD-AC：阴蒂至肛门；MRI-AGD-AF：后阴唇系带至肛门）。评估了AGD测量的可行性和观察者间可靠性。分析了患者组间AGD的差异。组内相关系数估计表明，MRI-AGD-AC具有良好至极好的可靠性（0.92；95%可信区间：0.83 - 0.95），而MRI-AGD-AF具有较差至良好的可靠性（0.68；95%可信区间：0.27 - 0.83）。在有或无深部浸润型子宫内膜异位症（DIE）手术诊断的患者中，平均MRI-AGD-AC和MRI-AGD-AF无统计学显著差异（p = 0.413；p = 0.110），在有或无DIE的腹膜型子宫内膜异位症患者中（p = 0.641；p = 0.323）以及卵巢型子宫内膜异位症患者中（p = 0.155；p = 0.150）也未发现统计学显著差异。曲线下面积（AUC）范围为0.475（95%可信区间：0.365 - 0.584）至0.586（95%可信区间：0.454 - 0.718）。因此，对于临床疑似子宫内膜异位症的患者，AGD并非一种有价值的生物标志物。
