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高血压中长链非编码RNA与微小RNA之间的相互作用

Interplay between lncRNAs and microrNAs in hypertension.

作者信息

Sudhakaran Gokul

机构信息

Center for Global Health Research, Saveetha Medical College and Hospital, Saveetha Institute of Medical and Technical Sciences (SIMATS), Thandalam, Tamil Nadu, India.

出版信息

Hypertens Res. 2025 Mar;48(3):1250-1251. doi: 10.1038/s41440-024-01888-0. Epub 2024 Dec 17.

Abstract

The interplay between long non-coding RNAs (lncRNAs) and microRNAs (miRNAs) in regulating hypertension modulate gene expression through different mechanisms, influencing key physiological and pathological processes. Specifically, interactions between lncRNAs and miRNAs affect various molecular pathways, including the renin-angiotensin-aldosterone system, which plays a critical role in blood pressure regulation. The lncRNA MALAT1 is particularly noted for its role in inflammation and oxidative stress regulation, suggesting potential targets for hypertension treatment and diagnostics. Interplay between lncRNAs and MicroRNAs in Hypertension.

摘要

长链非编码RNA(lncRNAs)与微小RNA(miRNAs)在调节高血压过程中的相互作用通过不同机制调节基因表达,影响关键的生理和病理过程。具体而言,lncRNAs与miRNAs之间的相互作用影响多种分子途径,包括在血压调节中起关键作用的肾素-血管紧张素-醛固酮系统。长链非编码RNA MALAT1因其在炎症和氧化应激调节中的作用而备受关注,提示其可能成为高血压治疗和诊断的潜在靶点。高血压中lncRNAs与微小RNA的相互作用。

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